NCT07369648Recruiting
Repetitive Transcranial Magnetic Stimulation for Motor Recovery After Ischemic Stroke (rTMS-MOTOR)
Effects of Repetitive Transcranial Magnetic Stimulation Combined With Motor Rehabilitation on Motor and Functional Outcomes in Patients With Ischemic Stroke: A Randomized Sham-Controlled Trial
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
Ischemic stroke is a leading cause of long-term motor disability, frequently resulting in hemiplegia and limitations in daily activities and quality of life. Motor rehabilitation is a fundamental component of post-stroke care across all stages of recovery; however, functional outcomes may vary, particularly in patients with persistent motor impairment. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has been used as an adjunct to rehabilitation to modulate cortical excitability and potentially support motor recovery. The purpose of this study is to evaluate the effects of low-frequency rTMS combined with conventional motor rehabilitation compared with sham rTMS combined with conventional motor rehabilitation in patients with first-ever ischemic stroke during the acute, subacute, and chronic stages. Motor function, balance, functional mobility, activities of daily living, and stroke-specific quality of life will be assessed at baseline, after the intervention, and at 3-month and 6-month follow-up.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 66 (estimated)
- First submitted
- 18 Jan 2026
- Start date
- 1 Feb 2026
- Primary completion date
- Jun 2027
- Lead sponsor
- Hanoi Medical University
- Diseases
- Stroke
- NCT number
- NCT07369648
What you commit to
- Study type: Interventional
- Planned participants: 66
- From 1 Feb 2026 to the primary completion date, Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Motor impairment caused by conditions other than ischemic stroke, such as musculoskeletal disorders, traumatic brain injury, Parkinson's disease, encephalitis, or other neurological conditions.
- Contraindications to repetitive transcranial magnetic stimulation, including but not limited to intracranial metallic implants, implanted electronic medical devices (e.g., pacemaker), cochlear implants, known bleeding disorders, pregnancy, history of epilepsy or seizure disorders, severe cardiac disease, severe psychiatric or neurological disorders interfering with participation, or active skin conditions at the stimulation site.
- History of epilepsy or seizure disorders.
- Recurrent stroke occurring during the intervention period.
Other
- Refusal to participate, withdrawal of informed consent, or non-adherence to the intervention protocol.
Who the study is looking for
- Aged 18 to 80 years.
- Diagnosed with a first-ever ischemic stroke, confirmed by neuroimaging.
- Presence of unilateral hemiparesis attributable to the first-ever ischemic stroke.
- Time since stroke onset:
- Acute stage: \< 1 month after stroke onset
- Subacute stage: 1 to 6 months after stroke onset
- Chronic stage: \> 6 months after stroke onset
- Moderate neurological impairment, defined as a baseline NIHSS score between 5 and 14.
- Cognitive ability sufficient to understand and follow instructions, indicated by a baseline MMSE score ≥ 20.
- Medically stable and able to participate in a structured motor rehabilitation program.
- Provided written informed consent prior to study enrollment.
- NIHSS and MMSE scores are assessed at baseline only to characterize neurological severity and cognitive status at study entry
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hanoi Rehabilitation Hospital Coordinator of this site? Confirm its status | Hanoi | Vietnam | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.