NCT07369778Not yet recruiting
Prospective Evaluation of Adler Laboratory's Massive Prosthetic Implants in Oncological and Non-oncological Situations
Source: ClinicalTrials.gov · Last updated 14 Apr 2026
Brief summary (registry, in English)
Massive prostheses are the standard treatment for extensive bone loss, whether caused by cancer or other factors (complex fractures, multiple revisions, infections). The emergence of modular systems such as the Pantheon range provides rapid restoration of function and precise intraoperative adaptation to anatomical constraints and specific bone loss characteristics. The Pantheon range also offers an innovative intramedullary ring system that promotes osseointegration and potentially long-term mechanical stability of implants. However, few studies have evaluated its clinical efficacy. In this context, a prospective cohort study is warranted in order to obtain robust data on implant survival, patient quality of life and predictors of medium- and long-term complications.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 375 (estimated)
- First submitted
- 19 Jan 2026
- Start date
- May 2026
- Primary completion date
- Jan 2030
- Lead sponsor
- Nantes University Hospital
- NCT number
- NCT07369778
What you commit to
- Study type: Observational
- Planned participants: 375
- From May 2026 to the primary completion date, Jan 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patient or parent of a minor patient who objects to participation in the study and data collection.
- Patient deprived of liberty or under legal protection (guardianship or curatorship)
Who the study is looking for
- Patients aged 15 years or older at the time of inclusion
- Surgery scheduled at one of the participating centres with an Adler implant from the list below:
- Implants from the Pantheon prosthesis:
- Proximal Femur Recontruction (PFR) Distal Femur Reconstruction (DFR) Proximal Tibia Reconstruction (PTR) Total Femur Reconstruction (TFR) Hybrid connector implants Custom-made implants
- Follow-up scheduled at one of the participating centres for the duration of the study
- Patient who has been informed about the study and does not object to participating In the case of minor patients, the patient's parents will also be informed, and their non-objection will be sought.
- Patient affiliated with a Social Security scheme in France.
Age in the registry: 15 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Nantes Coordinator of this site? Confirm its status | Nantes | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.