NCT07370818Not yet recruitingPhase 2
To Evaluate the Efficacy and Safety of JPI-547 in Combination With Bevacizumab as Maintenance Therapy in Relapsed Ovarian Cancer
An Open-label, Dose-finding and Randomized Active-controlled, Phase 2 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of JPI-547 With Bevacizumab Maintenance Therapy in Relapsed Ovarian Cancer Patients Previously Treated With PARP Inhibitor Maintenance Therapy and Responding to Last Platinum Chemotherapy
Source: ClinicalTrials.gov · Last updated 27 Jan 2026
Brief summary (registry, in English)
This study aims to to evaluate the efficacy, safety, and pharmacokinetics of JPI- 547 with bevacizumab maintenance therapy in relapsed ovarian cancer patients
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 81 (estimated)
- First submitted
- 12 Jan 2026
- Start date
- 27 Feb 2026
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- Onconic Therapeutics Inc.
- Diseases
- Ovarian cancer
- NCT number
- NCT07370818
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 81
- From 27 Feb 2026 to the primary completion date, 31 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with a history of severe drug hypersensitivity or hypersensitivity to the investigational drug, its components, or drugs within the same class.
- Patients with a confirmed specific medical history or a past surgical history.
- Those who have administered other investigational products or have received investigational medical device procedures within 4 weeks of the baseline
Other
- Individuals with dysphagia
- Patients with specific comorbidities or medical abnormalities.
- Pregnant women, lactating women, or women of childbearing potential who do not agree to use appropriate contraception during the clinical trial period and for 24 weeks after administration of the investigational medicinal product.
- Other patients who are inappropriate or unable to participate in this clinical study at the discretion of the investigator.
Who the study is looking for
- Histologically or cytologically confirmed recurrent ovarian cancer, fallopian tube cancer, or primary peritoneal cancer \[High-grade serous carcinoma (HGSC), Grade 2/3 endometrioid carcinoma\]
- Patients whose BRCA 1/2 gene mutation status and/or Homologous Recombination Deficiency (HRD) status.
- Patients who received platinum-based chemotherapy followed by PARP inhibitor maintenance therapy,
- Patients who had received chemotherapy before participating in the clinical trial and responded to platinum-based chemotherapy.
- Those with Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
- Individuals with confirmed adequate hematological, renal, and hepatic function (laboratory tests may be repeated once during the screening period)
Age in the registry: 19 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.