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NCT07370818Not yet recruitingPhase 2

To Evaluate the Efficacy and Safety of JPI-547 in Combination With Bevacizumab as Maintenance Therapy in Relapsed Ovarian Cancer

An Open-label, Dose-finding and Randomized Active-controlled, Phase 2 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of JPI-547 With Bevacizumab Maintenance Therapy in Relapsed Ovarian Cancer Patients Previously Treated With PARP Inhibitor Maintenance Therapy and Responding to Last Platinum Chemotherapy

Source: ClinicalTrials.gov · Last updated 27 Jan 2026

Brief summary (registry, in English)

This study aims to to evaluate the efficacy, safety, and pharmacokinetics of JPI- 547 with bevacizumab maintenance therapy in relapsed ovarian cancer patients

Status (registry)
Not yet recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
81 (estimated)
First submitted
12 Jan 2026
Start date
27 Feb 2026
Primary completion date
31 Dec 2029
Lead sponsor
Onconic Therapeutics Inc.
NCT number
NCT07370818

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 81
  • From 27 Feb 2026 to the primary completion date, 31 Dec 2029
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Patients with a history of severe drug hypersensitivity or hypersensitivity to the investigational drug, its components, or drugs within the same class.
  • Patients with a confirmed specific medical history or a past surgical history.
  • Those who have administered other investigational products or have received investigational medical device procedures within 4 weeks of the baseline

Other

  • Individuals with dysphagia
  • Patients with specific comorbidities or medical abnormalities.
  • Pregnant women, lactating women, or women of childbearing potential who do not agree to use appropriate contraception during the clinical trial period and for 24 weeks after administration of the investigational medicinal product.
  • Other patients who are inappropriate or unable to participate in this clinical study at the discretion of the investigator.

Who the study is looking for

  • Histologically or cytologically confirmed recurrent ovarian cancer, fallopian tube cancer, or primary peritoneal cancer \[High-grade serous carcinoma (HGSC), Grade 2/3 endometrioid carcinoma\]
  • Patients whose BRCA 1/2 gene mutation status and/or Homologous Recombination Deficiency (HRD) status.
  • Patients who received platinum-based chemotherapy followed by PARP inhibitor maintenance therapy,
  • Patients who had received chemotherapy before participating in the clinical trial and responded to platinum-based chemotherapy.
  • Those with Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
  • Individuals with confirmed adequate hematological, renal, and hepatic function (laboratory tests may be repeated once during the screening period)

Age in the registry: 19 years to - · Sex: Female · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine
Coordinator of this site? Confirm its status
SeoulSouth KoreaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.