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NCT07373015Not yet recruiting

Modified Double Snare Assisted EMR (mDS-EMR) VS ESD for Rectal Neuroendocrine Tumors Smaller Than 1cm

Comparision of Safety and Efficacy Between Modified Double Snare Assisted EMR (mDS-EMR) and ESD for Rectal Neuroendocrine Tumors Smaller Than 1cm: a Prospective Non-inferiority Randomized Controlled Study

Source: ClinicalTrials.gov · Last updated 28 Jan 2026

Brief summary (registry, in English)

The aim of this study is evaluating and safety and efficacy between the modified double snare EMR and ESD. It is intended to prove that for rectal neuroendocrine tumors within 1 cm, the complete resection rate of the mDS-EMR is not inferior to that of ESD, but may with shorter operation time, lower complication rate and lower treatment cost.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
118 (estimated)
First submitted
9 Jan 2026
Start date
1 Jan 2026
Primary completion date
31 May 2028
Lead sponsor
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
NCT number
NCT07373015

What you commit to

  • Study type: Interventional
  • Planned participants: 118
  • From 1 Jan 2026 to the primary completion date, 31 May 2028
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • With severe cardiovascular or cerebrovascular diseases and cannot tolerate operation( with a history of stroke or myocardial infarction within the past month or with severe heart failure and cardiac function grade III)

Lab values

  • Poor coagulation function(PT\>15 seconds or APTT\>45 seconds or INR\>2.0)

Other

  • Indication of metastasis by preoperative imaging examinations
  • With more than or equal to 2 rectal neuroendocrine tumors
  • With other complications that are not suitable for this study by multidisciplinary team assesment
  • Cases of recurrence after operation for neuroendocrine tumors

Who the study is looking for

  • Typical rectal neuroendocrine tumors by endoscopy (within 15cm from the anal verge, yellowish subepithelial elevation with a smooth surface, and dilated blood vessels in some areas).
  • The maximum diameter of the lesion is smaller than 1cm by preoperative endoscopic assessment.
  • Lesion is located within the mucosal and submucosal layer by preoperative endoscopic assessment.
  • Patients can understand and sign the informed consent.

Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.