NCT07374276Active, not recruiting
BCI With Virtual Reality for Stroke Rehabilitation: A Crossover Study
Brain-Computer Interface (BCI) With Virtual Reality (VR) in Upper Limb Rehabilitation After Stroke: A Randomized Crossover Clinical Trial
Source: ClinicalTrials.gov · Last updated 21 Sept 2026
Brief summary (registry, in English)
The goal of this clinical trial is to investigate if training sessions of motor imagery associated with brain-computer interface and motor observation through virtual reality (MI-VR-BCI) can help to improve arm and hand recovery after a stroke. The main questions to answer are: * Can adding MI-BCI-VR sessions improve upper limb movement? * Can it help stroke survivors perform daily activities more easily? * Does this type of training improve brain activity and connections related to movement? Researchers will compare this type of intervention with motor imagery associated with a standard brain-computer interface intervention (MI-BCI) to see if there are added effects to upper limb function, activity and brain connections. Participants will : * Perform two intervention periods in a random order: one with MI-VR-BCI training sessions and other with MI-BCI training sessions. Each period will involve 3 weekly sessions of training, during 6 weeks, with the intervention periods being separated by 3 weeks. * Complete four assessment sessions: one at the beginning and another at the end of each intervention period.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 9 Dec 2025
- Start date
- 5 Jan 2026
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Technical University of Lisbon
- Diseases
- Stroke
- NCT number
- NCT07374276
What you commit to
- Study type: Interventional
- Planned participants: 12
- From 5 Jan 2026 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant neurological or musculoskeletal conditions affecting upper limb motor function.
- Upper limb impairment due to a previous stroke.
Other illness
- Skin lesions, allergies, or metal implants in the cephalic region, or history of craniectomy, that hinder electrode placement or interfere with EEG signal acquisition.
- Other neurological, musculoskeletal, or psychiatric conditions that may compromise participation or study outcomes (e.g., major depression, severe visual impairment, photosensitive epilepsy, frequent vertigo or dizziness).
Other
- Severe communication difficulties preventing comprehension or execution of instructions.
Who the study is looking for
- Clinical diagnosis of stroke confirmed by neuroimaging, with resulting upper limb hemiparesis.
- Time since stroke between 6 and 24 months at the time of selection.
- Sufficient cognitive ability to understand and follow the intervention procedures.
- Spasticity score \<3 on the Modified Ashworth Scale in upper limb muscle groups.
- Adults aged 18 to 80 years.
- Ability to remain seated for approximately 2 hours.
- Motivation to participate and capacity to provide informed consent.
- Undergoing conventional rehabilitation therapy during the study period.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro de Medicina de Reabilitação de Alcoitão Coordinator of this site? Confirm its status | Alcabideche | Portugal | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.