NCT07375407Completed
Aerobic Exercise vs Physiological Ischemic Training in Stage 2 Hypertension
The Effect of Aerobic Exercise and Physiological Ischemic Training on VEGF, Interleukin-6, Interleukin-10, Cardiorespiratory Fitness, Muscle Strength, and Quality of Life in Patients With Hypertension
Source: ClinicalTrials.gov · Last updated 2 Feb 2026
Brief summary (registry, in English)
This study aims to compare the effects of aerobic exercise (AE) and physiological ischemic training (PIT) on inflammatory and angiogenesis biomarkers (VEGF, IL-6, IL-10), cardiorespiratory fitness, muscle strength, and quality of life in patients with grade 2 primary hypertension (HT2). This randomized controlled trial will involve 60 HT2 patients from Pratama and Utama Medika Antapani Clinic, who will be assigned to either AE or PIT groups. The intervention will last 6 weeks, and outcomes measured will include biomarker levels, VO2max, 6-minute walk distance (6-MWD), maximum voluntary contraction (MVC), and SF-36 questionnaire scores.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 21 Jan 2026
- Start date
- 5 Aug 2023
- Primary completion date
- 5 Dec 2023
- Lead sponsor
- Universitas Padjadjaran
- Diseases
- High blood pressure
- NCT number
- NCT07375407
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 5 Aug 2023 to the primary completion date, 5 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with unstable angina
- Malignant arrhythmias and high atrioventricular block
- Uncontrolled hypertension
- Severe valvular heart disease
- Chronic obstructive pulmonary disease
- Cor pulmonale and pulmonary vascular disease
- Cognitive impairment
- Subjects experiencing infection or inflammation
- Subjects with neuromuscular disorders that may affect the study results
- Subjects with musculoskeletal disorders that may affect the study results
- Complications or comorbidities such as cerebrovascular disease, CAD, atheroma plaques on imaging, heart failure, PAD, and atrial fibrillation.
Other
- Unstable hemodynamics
- Acute pericarditis
- Thrombophlebitis
- Intermittent claudication
- Uncooperative subjects
Who the study is looking for
- Primary hypertension patients aged 18-65 years
- Diagnosed with grade 2 primary hypertension
- Willing to participate in the study
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hasan sadikin general hospital Coordinator of this site? Confirm its status | Bandung | Indonesia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.