NCT07376850Not yet recruiting
Time in rANge vs. Time in nOrmal Glycemia for Better Glycemic Control
Source: ClinicalTrials.gov · Last updated 29 Jan 2026
Brief summary (registry, in English)
The TANGO study is a 12-month study involving 120 children and adolescents with Type 1 Diabetes (T1D) across the Czech Republic, Israel, and Poland who use automated insulin delivery (AID) systems. Currently, the global standard for diabetes management is "Time in Range" (TIR), which aims to keep blood sugar levels between 70-180 mg/dL. However, newer technologies like AID systems may now allow for a tighter, more physiological goal called "Time in Normal Glycemia" (TING), which targets a range of 70-140 mg/dL. This study will randomly assign participants to follow either the standard TIR target or the tighter TING target to see if the narrower range improves overall blood sugar control and HbA1c without increasing the risk of hypoglycemia, family stress, or daily treatment burden. By comparing these two approaches, researchers hope to determine if clinical guidelines should be updated to reflect a more precise glucose target for children and adolescents worldwide
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 22 Dec 2025
- Start date
- Jan 2026
- Primary completion date
- May 2026
- Lead sponsor
- University Hospital, Motol
- Diseases
- Type 1 diabetes
- NCT number
- NCT07376850
What you commit to
- Study type: Interventional
- Planned participants: 120
- From Jan 2026 to the primary completion date, May 2026
- 3 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- No concurrent illnesses impacting glycemia
Other illness
- Any significant diseases / conditions including psychiatric disorders and substance abuse that in the opinion of the investigator is likely to affect the subject's ability to complete the study or compromise participant's safety
Other
- No treatments impacting glycemia
- Severe hypoglycemia documented in the 60 day period leading up to patient recruitment
- Current participation in any other interventional study
- Female subject who is pregnant or lactating or planning to become pregnant within the planned study duration
Who the study is looking for
- Diagnosis of T1D per ADA criteria
- Age 5.0-17.99 at the start of study
- CGM use \>70% of the time during the month prior to enrollment
- Maximum HbA1c of 86mmol/mol (10% in DCCT)
Age in the registry: 5 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Motol University Hospital Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Schneider Children's Medical Center of Israel Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| Medical University of Warsaw Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.