NCT07379788Completed
ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling
Mitral Remodeling Index: A Novel Composite Measure the Effect of ARNI Alone Versus ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling.
Source: ClinicalTrials.gov · Last updated 2 Jun 2026
Brief summary (registry, in English)
This study aimed to compare the effects of ARNI monotherapy versus combined ARNI and SGLT2 inhibitor therapy on Mitral Remodeling Index (MRIx) and Functional mitral regurgitation (FMR) remodeling in patients with heart failure with reduced ejection fraction (HFrEF).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 180 (actual)
- First submitted
- 23 Jan 2026
- Start date
- 1 Jan 2025
- Primary completion date
- 28 Feb 2026
- Lead sponsor
- Rehab Werida
- Diseases
- Heart failure
- NCT number
- NCT07379788
What you commit to
- Study type: Interventional
- Participants enrolled: 180
- From 1 Jan 2025 to the primary completion date, 28 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- prior mitral valve surgery or transcatheter intervention,
Other illness
- primary (degenerative or rheumatic) mitral valve disease,
- acute decompensated heart failure within four weeks,
- significant primary valvular disease other than FMR,
- severe renal impairment (estimated glomerular filtration rate \<30 mL/min/1.73 m²),
Other
- inadequate echocardiographic image quality.
Who the study is looking for
- age ≥18 years;
- left ventricular ejection fraction (LVEF) \<50%;
- Presence of functional mitral regurgitation (mild, moderate, or severe) on transthoracic echocardiography; and
- stable sinus rhythm or controlled atrial fibrillation.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Madinah Cardiac Center Coordinator of this site? Confirm its status | Madinah | Saudi Arabia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.