NCT07381959Recruiting
Biomarkers of Brain Injury in Children With Brain Tumors
Biomarkörer för hjärnskada Hos Barn Med hjärntumör
Source: ClinicalTrials.gov · Last updated 2 Feb 2026
Brief summary (registry, in English)
The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors. The main question it aims to answer is: Can investigators identify sensitive plasma biomarker(s) of treatment-induced brain injury in children with primary brain tumors? Researchers will compare results between different treatment modalities (surgery, chemotherapy, radiation versus radiation-naive) and a healthy age- and sex-matched control population, to identify treatment-specific biomarkers. Participants will provide plasma samples at the following time points: before surgery, 1-2 weeks after surgery, as well as at 3-, 6-, 12-, 18-, 24-, and 36 months after surgery. Participants who receive radiation treatment will also provide plasma samples before and during treatment (approximately every 2 weeks). Where possible, plasma samples are also collected before the start of any new treatment (e.g., chemotherapy). Healthy controls will provide samples once.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 560 (estimated)
- First submitted
- 29 Dec 2025
- Start date
- 1 Aug 2021
- Primary completion date
- 31 Dec 2031
- Lead sponsor
- Uppsala University
- Diseases
- Childhood cancers
- NCT number
- NCT07381959
What you commit to
- Study type: Observational
- Planned participants: 560
- From 1 Aug 2021 to the primary completion date, 31 Dec 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have diagnosis of chronic disease that requires continuous medication.
Other
- Diagnosed with a tumor only in the spinal cord (solitary spinal tumor).
- Diagnosed with a tumor considered palliative already at diagnosis (e.g., diffuse intrinsic pontine glioma)
- Unable to provide informed consent due to language difficulties.
Who the study is looking for
- Age 0-17 years old, AND
- Diagnosed with primary brain tumor through surgery, biopsy, or other diagnostic method (e.g., for germinoma) at Uppsala University Hospital or at another university hospital in Sweden, AND
- Referred for radiotherapy at Skandion Clinic in Uppsala and/or at their local hospital (in some cases), with/without the addition of other cancer treatments.
- Age 0-17 years old, AND
- Diagnosed with primary brain tumor through surgery, biopsy, or other diagnostic method (e.g., for optic pathway glioma in neurofibromatosis type 1 and germinoma) at Uppsala University Hospital or at another university hospital in Sweden, AND
- Not referred to radiotherapy and treated with/without the addition of other cancer treatments.
- Age 0-17 years old at time of recruitment
Age in the registry: - to 17 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Uppsala University Coordinator of this site? Confirm its status | Uppsala | Sweden | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.