NCT07383220Recruiting
Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure
Effect of Combined Transcutaneous Electrical Stimulation and Isometric Exercise on Peripheral Hemodynamic Parameters in Patients With Resistant Hypertension
Source: ClinicalTrials.gov · Last updated 3 Feb 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if the combination between transcutaneous electrical nerve stimulation (TENS) and isometric exercise (IE) can improve blood pressure in men and women between 50 to 60 years old suffered from resistant hypertension which is a type of hypertension where blood pressure remains above your target goal despite the use of three or more different classes of antihypertensive medications at their maximum tolerated doses. The main question to answer is: Is there a significant effect on the combined use of TENS and IE on peripheral hemodynamic parameters in patients with resistant hypertension? Total sample will be 50 patients from both sexes I will compare between two groups: Experimental group (15 men, 10 women) will take: medication plus IE and TENS Control group (15 men, 10 women) will take: medication plus Conventional Physical Therapy Program
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 16 Jan 2026
- Start date
- 15 Jan 2026
- Primary completion date
- 30 May 2026
- Lead sponsor
- Mohamed Mohamed Ali Morgan
- Diseases
- Obesity, High blood pressure
- NCT number
- NCT07383220
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 15 Jan 2026 to the primary completion date, 30 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Secondary hypertension due to identifiable causes (e.g., renal artery stenosis, primary aldosteronism, pheochromocytoma).
- History of major cardiovascular events in the last 6 months (e.g., myocardial infarction, stroke, or heart failure exacerbation).
- Severe musculoskeletal or neurological disorders that impair the ability to perform isometric exercise safely (e.g., recent joint replacement, severe osteoarthritis, stroke with residual motor deficit).
- Contraindications to the use of Transcutaneous Electrical Nerve Stimulation (TENS):
- Implanted electronic devices: pacemakers, cardioverter defibrillators. Uncontrolled arrhythmias. Sever skin condition: open wounds, rashes, burns, eczema. Peripheral neuropathy or sensory loss.
- -Known cognitive impairment or psychiatric conditions that would limit the ability to follow instructions or provide informed consent.
Who the study is looking for
- Age between 50 and 60 years. Both sexes were included Patients had been diagnosed with hypertension for at least 5 years.
- Patients had resistant hypertension according to (Whelton et al 2018), defined as:
- Systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg despite the use of three or more antihypertensive medications of different classes, including a diuretic,
- or controlled blood pressure (\<140/90 mmHg) while on four or more antihypertensive medications.
- Body Mass Index (BMI) 25: 34.9 kg/m²
- Increased waist circumference, defined as:
- Greater than 102 cm for males.
- Greater than 88 cm for females.
Age in the registry: 50 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Out Clinics of Port Said Hospitals Coordinator of this site? Confirm its status | Port Said | Egypt | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.