Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients

Prior treatment

• 5.Use of other neuromodulatory therapies within the past 3 months;
• 8.Current use of medications that affect dopamine levels (e.g., antipsychotics);

Other illness

• 1.History or confirmed diagnosis of severe mental disorders, such as depression, anxiety disorders, schizophrenia spectrum disorders, and bipolar disorder;
• 2.The subject has clinically defined neurological conditions (assessed through self-report), including but not limited to: any disease potentially associated with increased intracranial pressure, space-occupying lesions, stroke history, transient ischemic attack (TIA) within the past two years, cerebral aneurysm, dementia, multiple sclerosis;
• 3.Severe cognitive impairment, Mini-Mental State Examination (MMSE) score \<22, or inability to independently complete questionnaires;
• 6.Presence of musculoskeletal or orthopedic conditions (e.g., severe arthritis, recent fractures) that significantly interfere with gait or balance;
• 7.Presence of metal implants (e.g., Deep Brain Stimulation, cardiac pacemakers) or contraindications for MRI/TIS;
• 9.Severe cardiovascular disease or other unstable medical conditions that preclude physical exertion or study participation;

Other

• 4.Inability to read or understand Chinese;

• 1.Aged 50 years or older;
• 2.Confirmed diagnosis of idiopathic Parkinson's disease (IPD) according to the 2015 MDS diagnostic criteria, with tremor and gait disturbance;
• 3.Disease duration ≥2 years after diagnosis, stable condition, and ability to cooperate with study assessment and intervention;
• 4.Stable medication dosage for at least 4 weeks prior to the trial;
• 5.Good response to Levodopa therapy;
• 6.Capable of independent walking (without assistive devices) for at least 5 minutes and able to complete gait testing independently.
• 7.Signed informed consent form, with the participant or their legal guardian able to understand and willing to participate in this study.