NCT07384897Recruiting
Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease
Source: ClinicalTrials.gov · Last updated 3 Feb 2026
Brief summary (registry, in English)
This study aims to better understand the role of immune system cells in lung diseases such as lung cancer, sarcoidosis, and chronic obstructive pulmonary disease (COPD). The investigators are studying how these immune cells can sometimes help the body defend itself, but in other cases may contribute to cancer growth or long-term lung inflammation. Although recent treatments like immunotherapy have improved cancer care, only a small proportion of patients currently benefit from these therapies. One goal of this research is to understand why some patients do not respond or develop resistance to treatment. The knowledge gained from this study may help researchers develop more effective and personalized treatments for people with lung diseases in the future.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 425 (estimated)
- First submitted
- 26 Jan 2026
- Start date
- 17 Feb 2025
- Primary completion date
- 1 Dec 2030
- Lead sponsor
- Université Catholique de Louvain
- Diseases
- COPD, Lung cancer, Childhood cancers
- NCT number
- NCT07384897
What you commit to
- Study type: Interventional
- Planned participants: 425
- From 17 Feb 2025 to the primary completion date, 1 Dec 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Systemic corticosteroid therapy \> 10 mg/day prednisone (or equivalent)
- Chronic inflammatory lung disease currently treated with immunosuppressive therapy
Other illness
- Acute infection at the time of inclusion
Other
- Refusal or inability to provide informed consent (or assent, when applicable)
Who the study is looking for
- Diagnosis of lung cancer
- Presence of precancerous lung lesions
- Patients with a chronic inflammatory lung disease (sarcoidosis or chronic obstructive pulmonary disease \[COPD\]) prior to any treatment
- Control group: individuals without known lung disease
- Children and adolescents weighing ≥ 10 kg with genetically confirmed chronic granulomatous disease (CGD)
- Adults scheduled to undergo orthopedic surgery during which a bone marrow sample will be collected
Age in the registry: - to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cliniques universitaires Saint-Luc Coordinator of this site? Confirm its status | Brussels | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.