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NCT07385040CompletedPhase 2/3

Comparison of IV Lignocain and IV Dexmedetomidine for Attenuation of Laryngoscopic Stress Response to Direct Laryngoscopy

Comparison of Intravenous Lignocain and Intravenous Dexmedetomidine for Attenuation of Hemodynamic Stress Response to Direct Laryngoscopy and Endotracheal Intubation

Source: ClinicalTrials.gov · Last updated 3 Feb 2026

Brief summary (registry, in English)

Hemodymanic stress response to direct laryngoscopy and endotracheal intubation is a known phenomenon that occur in almost every patient undergoing general anesthesia before surgical procedure. This response leads to sudden rise in heart rate and blood pressure which may cause serious complications in compromised patients having cardiovascular diseases. There are certain drugs which are used to blunt this response and to prevent the life threatening complications. Intravenous Lignocain is commonly used drug to blunt the laryngoscopic response in our setup. Intravenous Dexmedetomidine is a newer and rarely used drug to prevent stress response to direct laryngoscopy and endotracheal intubation. This study aims to compare the efficacy of both the drugs to provide better control of complications like Arrythmias, stroke and cardiovascular instability.

Status (registry)
Completed
Phase (registry)
Phase 2/3
Study type
Interventional
Enrollment
62 (actual)
First submitted
7 Dec 2025
Start date
13 Apr 2023
Primary completion date
31 Dec 2023
Lead sponsor
Shaheed Mohtarma Benazir Bhutto Institue of Trauma
NCT number
NCT07385040

What you commit to

  • Study type: Interventional · Phase 2/3
  • Participants enrolled: 62
  • From 13 Apr 2023 to the primary completion date, 31 Dec 2023
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Lack of consent Anticipated difficult airway Pregnancy Sensitivity to either drug

Who the study is looking for

  • Patients undergoing general anesthesia for any elective surgery Having ASA 1 or 2 Having mallapatti 1 or 2 Having BMI in between 18-30 kg/m2

Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Maryam
Coordinator of this site? Confirm its status
KarachiPakistanUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.