NCT07385898Completed
Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer
Source: ClinicalTrials.gov · Last updated 4 Feb 2026
Brief summary (registry, in English)
The primary change in aging lung tissue among older people is atrophy, leading to a significant decline in ventilatory function. Intraoperative mechanical ventilation further decreases lung compliance and ventilatory function in elderly patients, making them more susceptible to respiratory dysfunction and postoperative pulmonary complications, which severely affects patient safety and postoperative recovery. Dexmedetomidine is a highly selective α2-adrenergic receptor agonist, and several studies have found that intravenous infusion of dexmedetomidine exerted lung protective effects during single-lung ventilation thoracic surgery. However, one study found that continuous intravenous dexmedetomidine infusion during low-temperature cardiac arrest aortic surgery did not improve perioperative respiratory mechanics and oxygenation. Therefore, this project aims to investigate the lung protective effects of continuous intravenous infusion of dexmedetomidine during laparoscopic surgery for elderly patients with rectal or sigmoid colon cancer.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 64 (actual)
- First submitted
- 13 Dec 2023
- Start date
- 17 Apr 2023
- Primary completion date
- 3 Feb 2024
- Lead sponsor
- The Second Affiliated Hospital of Chongqing Medical University
- Diseases
- Lung cancer, Colorectal cancer
- NCT number
- NCT07385898
What you commit to
- Study type: Interventional
- Participants enrolled: 64
- From 17 Apr 2023 to the primary completion date, 3 Feb 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with acute coronary syndrome, sinus bradycardia (heart rate \<45 beats/minute), II or III degree atrioventricular block, or NYHA heart failure class III or IV
- Patients with a history of severe chronic obstructive pulmonary disease (COPD) (GOLD stage III or IV), severe or uncontrolled bronchial asthma, lung infections, bronchiectasis, thoracic deformities, and chest diseases (such as mediastinal tumors and thoracic tumors)
- Patients with stage 4 or 5 chronic kidney disease
Other
- Patients with obesity (BMI\>28 kg/m2)
- Grade 3 hypertensive patients (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg)
- Pulmonary artery pressure ≥ 60 mmHg
- Patients with Child-Pugh Class B or C liver function
- Patients with hyperthyroidism, pheochromocytoma
- Patients with hearing, intellectual, communication, or cognitive impairments
- Patients who cannot cooperate with the study for any reason, or whom the investigator deems unsuitable for inclusion in this trial.
Who the study is looking for
- Patients undergoing elective laparoscopic surgery for rectal or sigmoid colon cancer.
- American Society of Anesthesiologists (ASA) physical status classification I-III.
- Age ≥60 years and \<85 years.
- Voluntary participation and ability to understand and sign the informed consent form.
Age in the registry: 60 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Second Affiliated Hospital of Chongqing Medical University Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.