NCT07386418Recruiting
Study of Lesion-Specific Invasive Haemodynamic Angina Thresholds
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
ORBITA-SOLAR is an invasive physiological cardiac catheterisation study that aims to determine whether different coronary stenoses have different angina thresholds. The angina threshold is defined as the amount of coronary flow reduction required to reproduce symptoms. Sixty patients with symptoms of stable angina and 2 coronary artery stenoses amenable to percutaneous coronary intervention (PCI) will be recruited. This study will use intra-coronary balloon inflation during supine exercise to measure the fractional flow reserve (FFR) and non-hyperemic pressure ratio (NHPR) that corresponds to angina onset.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 19 Jan 2026
- Start date
- 10 Feb 2026
- Primary completion date
- Dec 2028
- Lead sponsor
- Imperial College London
- Diseases
- Coronary artery disease
- NCT number
- NCT07386418
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 10 Feb 2026 to the primary completion date, Dec 2028
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous coronary artery bypass graft
- PCI performed with drug-eluting balloons without stenting
- Contraindication to antiplatelet therapy
Other illness
- Acute coronary syndrome within 3 months
- Significant left main stem disease
- Moderate to severe valve disease
Lab values
- LVEF ≤40%, contraindication to PCI or drug-eluting stents
Age
- Age \<18 years
Other
- Single lesion amenable to PCI
- Chronic total occlusion of the target artery
- Contraindication to adenosine
- Physical inability to exercise with an ergometer
- Femoral artery access
- Pregnancy
- Inability to consent
Who the study is looking for
- Eligibility for PCI due to angina or angina-equivalent symptoms on exertion
- 2 severe epicardial stenoses in a major coronary artery, defined as:
- ≥70% stenosis in a coronary artery with ≥2.5mm diameter, on invasive coronary angiography (ICA)
- Severe stenosis in a vessel with ≥2.5mm diameter, on CTCA
- Evidence of ischaemia on an invasive or non-invasive test, including:
- Physiological test during invasive coronary angiography (ICA)
- Dobutamine stress echocardiography (DSE)
- Stress perfusion cardiac magnetic resonance (CMR)
- Myocardial perfusion scintigraphy (MPS)
- Fractional flow reserve computed-tomography (FFR-CT)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mid and South Essex NHS Foundation Trust Coordinator of this site? Confirm its status | Basildon | United Kingdom | Recruiting |
| University Hospitals Dorset NHS Foundation Trust Coordinator of this site? Confirm its status | Bournemouth | United Kingdom | Recruiting |
| Guy's and St Thomas' NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Not yet recruiting |
| Royal Free London NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| St. George's University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Chelsea and Westminster Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Imperial College Healthcare NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.