NCT07388004Recruiting
Group Therapy for Major Depression: Comparing Expectation-Focused and Reward-Focused Psychotherapy Approaches
Rewiring Expectations and Amplifying Rewards: A Study Protocol for a Randomized Controlled Trial of Mechanism-Based Group Psychotherapy for Major Depressive Disorder
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
Major depressive disorder (MDD) is one of the most common psychiatric conditions and often remains difficult to treat effectively. Many patients continue to experience residual symptoms or relapse even after receiving established forms of psychotherapy. This study tests whether targeting specific psychological mechanisms can improve outcomes for people with depression. We compare two novel group therapies: (1) Expectation-Focused Psychotherapeutic Intervention (EFPI), which aims to modify rigid, negative expectations that maintain depressive symptoms, and (2) Reward Enhancement and Activation Therapy (REACT), which focuses on increasing sensitivity to positive experiences and strengthening reward-related learning. Both are delivered in a group format to foster peer support and shared learning. A total of 150 adults with a current MDD diagnosis will be randomly assigned to EFPI, REACT, or a waiting-list control. Participants in the intervention groups receive 10 group sessions over five weeks. Waiting-list participants complete baseline and 3-month follow-up assessments before being offered standard treatment options. Clinical outcomes are assessed at baseline, immediately after treatment, and at 3- and 6-month follow-ups (for the intervention groups). Primary outcomes are reductions in depressive symptoms measured by clinician ratings and self-report questionnaires. Secondary outcomes include changes in expectation processes and reward sensitivity. In addition, functional MRI (fMRI) tasks examine brain mechanisms related to expectation updating and reward processing pre- and post-intervention, to help identify neural changes that may underlie symptom improvement. By directly addressing dysfunctional expectations and reduced reward sensitivity, this study seeks to provide evidence for more targeted psychotherapeutic approaches. If successful, the results may support more personalized treatments and better long-term outcomes in MDD.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 8 Dec 2025
- Start date
- 13 Oct 2025
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Philipps University Marburg
- Diseases
- Depression
- NCT number
- NCT07388004
What you commit to
- Study type: Interventional
- Planned participants: 150
- From 13 Oct 2025 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing psychotherapy or initiation of a new antidepressant medication within the past 4 weeks
- Insufficient German language proficiency to participate in therapy and complete study assessments
Other illness
- Current or lifetime diagnosis of bipolar disorder, psychotic disorder, or primary substance use disorder
- Severe neurological disorder, brain injury, or contraindications for MRI (e.g., metal implants, claustrophobia)
- Cognitive impairment or other conditions interfering with informed consent or study participation
Other
- High acute suicide risk requiring immediate intervention
Who the study is looking for
- Age: 18-80 years
- Current diagnosis of major depressive disorder (MDD) according to DSM-5, confirmed by structured clinical interview (e.g., DIPS)
- Hamilton Depression Rating Scale (HAMD-21) score ≥ 9
- Ability to attend group therapy sessions (2×/week for 5 weeks)
- Ability to undergo MRI scanning (for participants in the fMRI component) Written informed consent
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Philipps University Marburg Coordinator of this site? Confirm its status | Marburg | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.