NCT07388719Completed
Comparison of Standard Versus Dynamic Compliance-Guided Individualized PEEP in Obese Patients Undergoing Spinal Surgery
A Prospective Interventional Study Comparing Standard and Dynamic Compliance-Guided Individualized Positive End-Expiratory Pressure on Intraoperative Oxygenation and Postoperative Pulmonary Complications in Obese Patients Undergoing Spinal Surgery
Source: ClinicalTrials.gov · Last updated 5 Feb 2026
Brief summary (registry, in English)
This study aims to compare standard positive end-expiratory pressure (PEEP) with dynamic compliance-guided individualized PEEP in obese patients undergoing elective spinal surgery under general anesthesia. Obesity and prone positioning during spinal surgery are associated with reduced lung compliance, atelectasis, and an increased risk of postoperative pulmonary complications. Participants will be allocated to receive either a fixed standard PEEP or an individualized PEEP level determined according to intraoperative dynamic lung compliance. Intraoperative oxygenation, respiratory mechanics, arterial blood gas parameters, and hemodynamic variables will be assessed at predefined time points. Postoperative pulmonary complications within the first 24 hours after surgery will also be evaluated. The study seeks to determine whether individualized PEEP titration based on dynamic compliance offers physiological or clinical advantages compared with a standard PEEP strategy in this patient population.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 80 (actual)
- First submitted
- 28 Jan 2026
- Start date
- 2 Feb 2025
- Primary completion date
- 12 Dec 2025
- Lead sponsor
- Konya City Hospital
- Diseases
- Obesity
- NCT number
- NCT07388719
What you commit to
- Study type: Interventional
- Participants enrolled: 80
- From 2 Feb 2025 to the primary completion date, 12 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Emergency surgery
Other illness
- Pre-existing severe pulmonary disease (e.g., COPD GOLD stage III-IV, restrictive lung disease)
- History of thoracic surgery affecting lung mechanics
Lab values
- Severe cardiac disease (e.g., heart failure with reduced ejection fraction, significant valvular disease)
Other
- Pregnancy
- Intraoperative need for deviation from the planned ventilation protocol
Who the study is looking for
- Adult patients aged 18-65 years
- Body mass index (BMI) ≥30 kg/m²
- Scheduled for elective spinal surgery under general anesthesia
- Requirement for intraoperative mechanical ventilation
- American Society of Anesthesiologists (ASA) physical status II-III
- Provision of written informed consent
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Konya City Hospital Coordinator of this site? Confirm its status | Konya | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.