NCT07388849Not yet recruiting

A Longitudinal Follow-Up Study on Predicting Major Depressive Disorder From Rest-Activity Rhythm Profiles

Can Rest-Activity Rhythm Profiles Predict Major Depressive Disorder? A Longitudinal Follow-up Study

Source: ClinicalTrials.gov · Last updated 5 Feb 2026

Brief summary (registry, in English)

This proposed study will be a longitudinal follow-up study of a case-control study of 160 participants (CREC Ref: 2023.234). This study aims to follow up on the trajectory of depression and rest-activity rhythm (RAR) disruptions, as well as examine their association over time. The investigators aim to identify distinctive RAR profiles of MDD using the data from the original project and hypothesize that two or more groups will be identified based on individual RAR variables using cluster analysis. The investigators hypothesize that significant differences in depressive symptom severity, sleep quality, and other outcome measures collected in this follow-up will be found between the clustered groups. Individuals exhibiting the most disrupted RAR profiles are hypothesized to have the greatest deterioration in depression symptom severity and other outcome measures. The investigators also hypothesize that people persisting with MDD will exhibit greater disruptions in RAR compared to those without MDD at the follow-up. Furthermore, the investigators will examine whether individual RAR parameters are longitudinally associated with changes in depression symptom severity and other outcome measures.

Status (registry): Not yet recruiting
Study type: Observational
Enrollment: 160 (estimated)
First submitted: 16 Jan 2026
Start date: 1 Feb 2026
Primary completion date: 31 Dec 2028
Lead sponsor: Chinese University of Hong Kong
Diseases: Depression
NCT number: NCT07388849

What you commit to

Study type: Observational
Planned participants: 160
From 1 Feb 2026 to the primary completion date, 31 Dec 2028
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

An unstable use of psychotropic drugs (medication use has to remain stable for at least 6 weeks before baseline assessment)

Other illness

Severe medical or neurocognitive disorders that make participation unsuitable
History of electroconvulsive therapy (ECT)
Presence of other untreated sleep disorders, including narcolepsy, obstructive sleep apnoea (OSA), and restless leg syndrome (RLS)/periodic leg movement disorder (PLMD) based on the cut-off scores of individual sections in SLEEP-50 (narcolepsy ≥ 7; OSA ≥ 15; RLS/PLMD ≥ 7)

Other

Current involvement in any psychological treatment program that targets depression and/or sleep problems
The investigators will not exclude those with current suicidal risks (i.e., non-fleeting intent or plan), which is a common symptom of MDD. However, if serious suicidal risk (i.e., PHQ-9 Item 9 score \> 2) is identified, the participant will be referred to the PI (a clinical psychologist) for further assessment and professional mental health services if deemed necessary.
Shift work, pregnancy, work, family, or other commitments that interfere with regular sleep-wake patterns

Who the study is looking for

Hong Kong residents aged 18 to 70 years
Chinese language fluency
Accessibility to an Internet-enabled mobile device
A willingness to provide informed consent and comply with the study protocol

Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
The Chinese University of Hong Kong Coordinator of this site? Confirm its status	Hong Kong	Hong Kong SAR China	Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.