NCT07389005Recruiting
Exercise, Chronotype, and Prediabetes
Timed Exercise in Prediabetes With Extreme Chronotype
Source: ClinicalTrials.gov · Last updated 11 Sept 2026
Brief summary (registry, in English)
The goal of this clinical trial is to find out whether exercising at the right time of day, based on a person's natural body clock, leads to greater health benefits in people living with prediabetes. The main question it aims to answer is whether doing a single session of exercise in the morning or in the evening affects how the body handles sugar differently in adults with prediabetes who have an extreme natural body clock. This will be done by comparing three conditions (no-exercise, morning exercise, and evening exercise) within the same participant. Each condition will be tested on a different day, with at least 14 days between the test days. During the no-exercise test days, participants will come to the study centre and will only be allowed to do sedentary activities (e.g. office work, reading, or screen time). During the morning exercise test days, participants will perform an exercise session at 9:00 am that involves short periods of very hard effort followed by short rest periods. Whereas for the evening exercise test days, the same type of exercise will be performed at 5:00 pm.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 28 (estimated)
- First submitted
- 20 Jan 2026
- Start date
- Sept 2026
- Primary completion date
- Aug 2028
- Lead sponsor
- German Diabetes Center
- Diseases
- Obesity
- NCT number
- NCT07389005
What you commit to
- Study type: Interventional
- Planned participants: 28
- From Sept 2026 to the primary completion date, Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previously diagnosed with type 2 diabetes
- Medication use known to hamper safety during the study procedures
Other illness
- Uncontrolled hypertension
- HIV, hepatitis B, or C infection
- Disorders of blood clotting or wound healing
- Positive history of venous thrombosis (contraindication for clamp)
- Hypersensitivity to local anesthetics (contraindication for fat/muscle biopsies)
- Any acute condition, exacerbation of chronic condition, or medical history that in the investigator's opinion would interfere with the study
Lab values
- Moderate to severe anemia (hemoglobin \< 10 g/L)
Other
- Abnormal electrocardiogram (ECG) at rest judged by the study physician
- Pregnancy or breastfeeding
- Night shift work in the last 3 months
- Travel across \> 1 time zone in the last 3 months
- Participation in another clinical trials that may possibly hamper the study results
- Engagement in structured exercise activities \> 2 hours a week
- Any contraindication for MRI scanning
- Non-German speaking
Who the study is looking for
- Able to provide signed and dated written informed consent prior to any study specific procedures
- Adult men and women aged between more than 18 and ≤ 75 years
- Body mass index (BMI) of 25 - 35 kg/m2
- Stable weight (no weight loss or gain \> 3 kg in the past 3 months)
- Pre-diabetes defined as an isolated impaired glucose tolerance or a combination of impaired glucose tolerance and impaired fasting glucose (values are based on the American Diabetes Association (ADA):
- impaired glucose tolerance (plasma glucose 140 mg/dL to 199 mg/dL, 120 minutes after consumption of 75g of glucose)
- impaired fasting glucose (fasting plasma glucose 100 mg/dL to 125 mg/dL)
- Morning (Morningness-Eveningness Questionnaire \[MEQ\] score ≥ 59) or evening (MEQ score ≤ 41) chronotype
Age in the registry: 19 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| German Diabetes Center (DDZ) Coordinator of this site? Confirm its status | Düsseldorf | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.