NCT07389447Active, not recruiting
Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity
FUS of the Dentate Nucleus and Superior Cerebellar Peduncle of the Cerebellum Induces Changes to EEG Power Bands, Spatiotemporal Dynamics, and Cognitive Function in Healthy Humans
Source: ClinicalTrials.gov · Last updated 5 Feb 2026
Brief summary (registry, in English)
The goal of this preclinical study is to assess the effects of focused ultrasound stimulation to the cerebellum on brain dynamics and cognition in healthy volunteers aged 18 to 40. The main questions it aims to answer are: Does FUS applied to the cerebellum affect cognition? Does FUS applied to the white matter or gray matter of the cerebellum with the same parameters result in different outcomes? Researchers will compare active and sham stimulations. Participants will be asked to complete cognitive tasks after receiving FUS to the cerebellum.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 6 Aug 2025
- Start date
- 5 Feb 2024
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- University of Nottingham
- Diseases
- Stroke
- NCT number
- NCT07389447
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 5 Feb 2024 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants must not have implanted material (e.g., pacemaker, neurostimulator, medication infusion device, cochlear implants).
- Participants must not be currently taking psychoactive medication, or must have stopped taking such medication for at least 2 weeks before starting experiment (excluding contraception).
- Participants must abstain from the use of any recreational drugs in the 48-hour period prior to taking part in the experiment.
Other illness
- Participants must not have history of neurological or psychiatric disorder.
- Participants must not have skin disease on or close to the scalp.
- Participants must not have direct relatives (parents, siblings, children) with epilepsy, convulsion, or seizure.
Other
- Participants must not have claustrophobia or anxiety regarding MRI scan.
- Participants must not have current or planned pregnancy.
- Participants must not have predisposition for fainting spells (syncope).
- Participants must not have medical patch that cannot or may not be taken off (e.g., nicotine patch).
- Participants must not consume more than 4 alcoholic units within the 24-hour period before participation.
Age in the registry: 18 years to 40 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Precision Medical Imaging, QMC Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.