NCT07389772Enrolling by invitation
INVESTIGATION OF THE EFFECT OF DIFFERENT ACTIVATION TECHNIQUES ON TLR9, IL6, IL10, TNF-ALFA LEVELS IN HEALTHY AND TYPE 2 DIABETIC PATIENTS WITH APICAL PERIODONTITIS REQUIRING RETREATMENT
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
The subject of this thesis study is the effects of SWEEPS laser and ultrasonic activation methods on the immune response in the treatment of apical periodontitis in healthy individuals and patients with Type 2 diabetes requiring retreatment, based on a comparative investigation of Toll-like Receptor 9 (TLR-9), Interleukin-6 (IL-6) and Tumour Necrosis Factor alpha (TNF-α), and Interleukin-10 (IL-10) levels.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 90 (estimated)
- First submitted
- 29 Jan 2026
- Start date
- 28 Jan 2026
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- bengisu yüksel
- Diseases
- Type 2 diabetes
- NCT number
- NCT07389772
What you commit to
- Study type: Observational
- Planned participants: 90
- From 28 Jan 2026 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with inflammatory or autoimmune diseases such as hepatitis, HIV infection, immunosuppressive chemotherapy, bleeding disorders, Behçet's syndrome, and arthritis,
Lab values
- Individuals with HbA1c levels above 9%,
- 5\. Those who have used antibiotics within the last month and anti-inflammatory drugs within the last week, 6. Smokers, 7. Patients with periodontal pockets greater than 3 mm in the relevant tooth, 8. Those with internal or external root resorption, 9. Those with swelling, palpation pain, or a fistula in the relevant area, 10. Those with root fracture or incomplete root formation, 11. Teeth that cannot be isolated with a rubber dam will not be included in the study.
- The name, surname, age, gender, contact information, and tooth number to be treated of patients included in the study will be recorded on the case report form. Periapical radiographs will be taken of the relevant teeth prior to root canal treatment to examine the root canal anatomy. The periapical health status of each tooth will be assessed using the PAI score.
Other
- ASA II or higher,
- Pregnant women or those suspected of being pregnant,
- Patients with localized or generalized periodontitis,
Who the study is looking for
- Inclusion criteria for the study:
- Patients aged 18-50 years
- Patients with ASA I status
- Patients with Type 2 diabetes whose HbA1c values are between 5.5% and 9.0%, with diabetes diagnosis confirmed by medical history and laboratory tests (HbA1c test)
- Upper and lower incisors and lower premolars with chronic apical periodontitis,
- Teeth requiring retreatment with a PAI score ≥3 will be included in the study. (15)
Age in the registry: 18 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kirikkale University Faculty of Dentistry Coordinator of this site? Confirm its status | Kirikkale | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.