NCT07392749Recruiting
Feasibility Study of Diaphragm Synchronized Pacing (DSP) Via the Left Inferior Phrenic Vein (LIPV) Approach
Source: ClinicalTrials.gov · Last updated 6 Feb 2026
Brief summary (registry, in English)
Cardiac resynchronization therapy（CRT） benefits a portion of patients, while more patients are not yet indicated to a therapy that mechanically helps the heart systole and/or diastole. Synchronized diaphragmatic pacing may be feasible to induce diaphragm local contraction and recoil that enhance pump function of the heart, thus improve cardiac function and QoL. This acute, interventional study is conducted in a single site, Renji Hospital, to evaluate the feasibility of diaphragm pacing and assess the beneficial effect of pacing-regulated diaphragm movement to the heart, with 10 cases of sample size and one-week follow-up after discharge.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 8 Dec 2025
- Start date
- 28 Nov 2025
- Primary completion date
- 28 Feb 2026
- Lead sponsor
- RenJi Hospital
- Diseases
- Heart failure
- NCT number
- NCT07392749
What you commit to
- Study type: Interventional
- Planned participants: 10
- From 28 Nov 2025 to the primary completion date, 28 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Abdominal surgery history
Other illness
- Ischemic heart disease with CABG history
- Pulmonary disease
Other
- CRT or CRT-D replacement
- Diaphragm dysfunction history
- Phrenic nerve injury
- IVC filter history
- Splenomegaly
- Moderate or severe liver cirrhosis
- Severe hepatic or renal dysfunction
- Currently pregnant or planning pregnancy during the study period
- Patients participate in another study that will confound this study
Who the study is looking for
- Patients aged \>=18 yrs;
- Patients indicated for CRT or CRT-D , planned for LV lead implantation;
- Patients are willing to participate in the study and provide signed informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| RenJi Hospital Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.