NCT07393113Completed
CLarifying ABCB1's Role in Alzheimer's Disease
CLarifying ABCB1's Role in Amyloid Efflux and Alzheimer's Disease Risk
Source: ClinicalTrials.gov · Last updated 6 Feb 2026
Brief summary (registry, in English)
Alzheimer's disease is biologically defined by the accumulation of amyloid beta and tau protein, identified using cerebrospinal fluid biomarkers. The ABCB1 gene, which encodes P-glycoprotein involved in amyloid beta efflux across the blood-brain barrier, may influence Alzheimer's disease risk. We hypothesize that certain functional ABCB1 polymorphisms impair amyloid beta clearance, thereby promoting the development of biologically defined Alzheimer's disease.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 510 (actual)
- First submitted
- 19 Jan 2026
- Start date
- Oct 2023
- Primary completion date
- Dec 2025
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Alzheimer disease
- NCT number
- NCT07393113
What you commit to
- Study type: Observational
- Participants enrolled: 510
- From Oct 2023 to the primary completion date, Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- the presence of an active non-degenerative neurological disorder (for example, multiple sclerosis, infections, or tumors),
Other
- and missing data regarding APOE genotyping or cardiovascular risk factors
Who the study is looking for
- age ≥ 50 years,
- available cerebrospinal fluid biomarker results,
- an available and usable DNA sample,
- and consent for future research use within the biobank.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopital Lariboisiere - Fernand-Widal - AP-HP Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.