NCT07394530Recruiting
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
A Comparative Study of In Vitro Fertilization Outcomes Between PPOS and Antagonist Protocols in Women With Polycystic Ovary Syndrome
Source: ClinicalTrials.gov · Last updated 5 Aug 2026
Brief summary (registry, in English)
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 400 (estimated)
- First submitted
- 30 Jan 2026
- Start date
- 20 Jan 2026
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Hanoi General Hospital (Vietnam)
- NCT number
- NCT07394530
What you commit to
- Study type: Interventional
- Planned participants: 400
- From 20 Jan 2026 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
- History of recurrent pregnancy loss (≥3 spontaneous miscarriages)
Other
- Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology.
- Known chromosomal abnormalities in either partner
- Inability to adhere to study protocol or follow-up procedures
Who the study is looking for
- Women aged 18-40 years
- Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
- Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI)
- Eligible for controlled ovarian stimulation for IVF
- Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT)
- Willing and able to provide written informed consent and comply with study procedures.
Age in the registry: 18 years to 40 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hanoi General Hospital Coordinator of this site? Confirm its status | Hanoi | Vietnam | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.