NCT07394842Active, not recruiting
Longitudinal Oral Health Changes After Head and Neck Radiotherapy
Longitudinal Effects of Head and Neck Radiotherapy on Periodontal and Dental Oral Health: A Prospective Cohort Study
Source: ClinicalTrials.gov · Last updated 6 Feb 2026
Brief summary (registry, in English)
This prospective observational study evaluates how head and neck radiotherapy affects oral health over time. Patients with head and neck cancer undergoing standard radiotherapy are followed from before treatment through multiple post-treatment visits. Changes in periodontal health, dental status, salivary function, and patient-reported oral health quality of life are assessed. The study aims to better understand the long-term oral complications of radiotherapy and to support improved preventive and supportive dental care for cancer patients.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (actual)
- First submitted
- 31 Jan 2026
- Start date
- 1 Feb 2025
- Primary completion date
- 1 Feb 2026
- Lead sponsor
- Ain Shams University
- Diseases
- Head and neck cancer
- NCT number
- NCT07394842
What you commit to
- Study type: Observational
- Participants enrolled: 100
- From 1 Feb 2025 to the primary completion date, 1 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous head and neck radiotherapy
- Current bisphosphonate or anti-resorptive therapy
- Severe periodontal destruction requiring immediate surgical intervention
Other illness
- Autoimmune salivary gland disorders
Lab values
- Uncontrolled systemic disease (HbA1c \>9% for diabetic patients)
Other
- Pregnancy
Who the study is looking for
- Age ≥18 years
- Histologically confirmed head and neck malignancy
- Planned radiotherapy dose ≥50 Gy
- Presence of at least 20 natural teeth
- No periodontal treatment during the preceding 6 months
- Ability to comply with the scheduled follow-up visits
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ahmed Maher Teaching Hospital Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.