NCT07396025Enrolling by invitation
Effectiveness of Surgical and Diagnostic Methods in Cerebral Vascular Occlusive Disease
Evaluation of the Effectiveness of Surgical and Diagnostic Techniques in Patients With Steno-occlusive Diseases of the Cerebral Vessels
Source: ClinicalTrials.gov · Last updated 9 Feb 2026
Brief summary (registry, in English)
This study attempts to improve surgical treatment outcomes among people with chronic carotid artery occlusive disease by conducting a comprehensive review of neuroradiological, clinical, and cognitive data. The evaluation involves an extensive angiographic analysis, including pre- and postoperative measurements of superficial temporal artery branch diameters, assessment of the Circle of Willis and collateral pathways, alongside cerebral perfusion metrics, cognitive status, and clinical outcomes. Major focus is directed towards evaluating the degree of intracranial revascularization following to extracranial-intracranial bypass by postoperative angiographic evaluations. This integrative strategy aims to refine surgical reasons, better predictions of functional and cognitive outcomes, minimize postoperative risks, and eventually improve the overall efficacy of treatment in this patient population.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 28 Jan 2026
- Start date
- 9 Jul 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- National Centre for Neurosurgery, Republic of Kazakhstan
- Diseases
- Stroke
- NCT number
- NCT07396025
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 9 Jul 2025 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications to MRI, CTA, DSA, iodinated contrast agents, or antiplatelet therapy required in the perioperative period.
- Participation in another interventional or experimental trial within the previous 12 months, including studies involving ionizing radiation
- \-
Other illness
- Patients with severe somatic conditions or mRS score \> 3
- Patients with bilateral ICA occlusion, neurovascular disease (cerebral aneurysm or arteriovenous malformation)
Lab values
- Cardiac conditions associated with a high risk of cerebral embolism, including prosthetic heart valves, infective endocarditis, intracardiac thrombus, sick sinus syndrome, cardiac myxoma, or cardiomyopathy with left ventricular ejection fraction \<25% (atrial fibrillation, patent foramen ovale, and atrial septal aneurysm are not exclusion criteria).
Age
- Patients aged under 18
- Severe systemic comorbidities, life expectancy \<2 years, or a modified Rankin Scale (mRS) score \>3.
Other
- Patients with large territorial infarction or marked cerebral atrophy on MRI.
- No evidence of regional hypoperfusion on ASL MRI relative to the contralateral hemisphere.
- Patients with a non-functioning STA-MCA bypass
- Patients with Contraindications to MRI, CTA, or DSA
- Pregnancy.
Who the study is looking for
- Patients with ICA occlusion confirmed by CTA, MRA, and cerebral DSA.
- MRI ASL-confirmed hypoperfusion in the territory of the occluded ICA (decrease of ≥30% compared with the contralateral side)
- Language comprehension is preserved, with mild or no motor aphasia and no significant cognitive impairment.
- Patients aged from 18 to 80 years.
- Modified Rankin Scale (mRS) score 0-2.
- Informed consent is available from the patient or legal guardian.
- Accessible and reliable patients for follow-up
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Centre for Neurosurgery Coordinator of this site? Confirm its status | Astana | Kazakhstan | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.