NCT07397650RecruitingPhase 4
Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With Heart Failure
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
FACILITATE-HF is a multicenter, randomized, double-blind, placebo-controlled trial designed to determine whether initiation of finerenone during the early phase of hospitalization has beneficial effects in patients with AHF who have left ventricular ejection fraction 40% or more.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 550 (estimated)
- First submitted
- 2 Feb 2026
- Start date
- 11 May 2026
- Primary completion date
- Dec 2027
- Lead sponsor
- Juntendo University
- Diseases
- Heart failure
- NCT number
- NCT07397650
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 550
- From 11 May 2026 to the primary completion date, Dec 2027
- 21 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Systemic therapy with potent cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors or inducers within 7 days before randomization or is expected to be used during the study period (e.g. itraconazole, ritonavir, indinavir, cobicistat, clarithromycin).\<br\>
- Participants who require treatment with more than one ACEI, ARB or angiotensin-receptor neprilysin inhibitor (ARNI) simultaneously\<br\>
- Acute coronary syndrome, pulmonary thromboembolism, stroke, or transient ischemic attack within 90 days before randomization.\<br\>
- Have undergone the following therapeutic intervention within 30 days before randomization: cardiovascular surgery (e.g., coronary artery bypass grafting, surgery for valvular heart disease, transcatheter aortic valve implantation, percutaneous coronary intervention, percutaneous edge-to-edge mitral valve repair, and other types of surgery at the investigator's discretion) and implantation of an implantable defibrillator, or a cardiac resynchronization therapy defibrillator.\<br\>
- Peripartum cardiomyopathy diagnosed within 6 months before randomization.\<br\>
- Patients with symptomatic bradycardia or complete atrioventricular block who are being treated with temporary pacemaker implantation at the time of admission, or who are expected to require temporary or permanent pacemaker implantation in the future. Patients who have already been treated with permanent pacemaker implantation do not meet the exclusion criteria\<br\>
- Participation in another interventional clinical study (e.g. phase 1 to 3 clinical studies) or treatment with another investigational medicinal product within 30 days prior to randomization.Other conditions likely to interfere with the patient's safety or compliance with the protocol\<br\>
Other illness
- Known hypersensitivity to the study intervention (active substance or excipients)\<br\>
- Acute heart failure in which other diseases are the main cause of symptoms and signs (chronic obstructive pulmonary disease, anemia, etc.)\<br\>
- Heart transplant recipients or patients listed for heart transplantation who are expected to undergo transplantation during the study, patients implanted with an implantable ventricular-assist device, patients expected to require an implantable ventricular-assist device during the study, and patients expected to switch to palliative care during the study.\<br\>
- Coronary or valvular heart disease likely to require surgical or percutaneous intervention within the study period (there is no reason to exclude secondary mitral or tricuspid regurgitation due to reduced cardiac function, except for the absence of a plan to perform cardiac surgery or therapeutic catheterization)\<br\>
- Secondary cardiomyopathy such as amyloidosis, cardiac sarcoidosis, hemochromatosis, Fabry's disease, chemotherapy induced cardiomyopathy, and muscular dystrophy. Heart failure due to takotsubo cardiomyopathy, obstructive hypertrophic cardiomyopathy, complex congenital heart disease (as determined by the investigator), pericardial constriction, right heart failure in absence of left-sided structural disease\<br\>
- Acute cardiac structural abnormalities (e.g., acute mitral regurgitation due to ruptured chordae tendineae and infective endocarditis)\<br\>
- Presence of uncontrolled thyroid disease\<br\>
- Addison's disease\<br\>
- Hepatic insufficiency classified as Child-Pugh C \<br\>
- Any other condition or therapy, which would make the participant unsuitable for this study and will not allow participation for the full planned study period (e.g. active malignancy or other condition limiting life expectancy to less than 12 months)\<br\>
- Patients with dementia. If a sub-investigator determines that confirmation of cognitive impairment is necessary, it must be verified that the Mini-Cog score is not less than 4.\<br\>
Lab values
- Estimated glomerular filtration rate (eGFR) \<25 mL/min/1.73m2 by CKD-EPI Creatinine Equation (2021) at screening\<br\>
- Serum/plasma potassium \>5.0 mmol/L at screening\<br\>
- Use of eplerenone, spironolactone, esaxerenone or potassium-sparing diuretic within 30 days before randomization \<br\>
Other
- Patients who cannot receive oral treatment\<br\>
- Patients who are on dialysis including peritoneal dialysis or in whom the initiation of dialysis during the study period\<br\>
- Pregnant or lactating female\<br\>
- Active myocarditis at randomization.\<br\>
- Patients with excessive alcohol intake (15+ drinks/week for men, 8+ drinks/week for women)\<br\>
- Patients deemed unsuitable by the principal investigator or sub investigator
Criteria the registry did not label
- Patients eligible for inclusion in this study meet all of the following criteria: \<br\>Inclusion Criteria:
- Patients ≥18 years of age, male or female\<br\>
- Current hospitalization with AHF requiring intravenous loop diuretics or vasodilators during the index admission\<br\>
- Patients have to have at least one of new or worsening symptoms due to HF and one of new or worsening physical examination findings due to HF \<br\> (i) symptom\<br\> dyspnoea, decreased exercise tolerance, or fatigue\<br\> (ii) physical examination\<br\> peripheral edema, increasing abdominal distention or ascites, pulmonary rales/crackles/crepitations, increased jugular venous pressure and/or hepatojugular reflux, S3 gallop, clinically significant or rapid weight gain\<br\>
- Patients who are not hemodynamically unstable as defined by meeting the following criteria\<br\>
- Systolic blood pressure ≥100 mmHg and no symptoms of hypotension within 6 hours prior to randomization\<br\>
- No increase in intravenous diuretic dose or intravenous vasodilators within 6 hours prior to randomization with worsening HF symptom\<br\>
- Without cardiogenic shock, no use of inotropes or vasopressors, no use of mechanical circulatory support, not requiring intubation after admission, and not expected to require inotropes, vasopressors, mechanical circulatory support or intubation during the index hospitalization\<br\>
- NTproBNP ≥1500 pg/mL or BNP ≥375 pg/mL (For patients treated with ARNI in the previous 4 weeks prior to randomization, only NT-proBNP values should be used)\<br\>
- Most recent LVEF ≥40% within the past 1 year \<br\>
- Randomization within 24 hours after admission, and drug administration within 36 hours after admission \<br\>
- Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol\<br\>
- Signed informed consent must be obtained prior to participation in the study\<br\>
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (21)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Japanese Red Cross Fukuoka Hospital Coordinator of this site? Confirm its status | Fukuoka | Japan | Not yet recruiting |
| Chita Peninsula General Medical Center Coordinator of this site? Confirm its status | Handa | Japan | Recruiting |
| Iizuka Hospital Coordinator of this site? Confirm its status | Iizuka | Japan | Recruiting |
| Juntendo University Shizuoka Hospital Coordinator of this site? Confirm its status | Izunokuni | Japan | Not yet recruiting |
| Chutoen General Medical Center Coordinator of this site? Confirm its status | Kakegawa | Japan | Recruiting |
| Saitama Medical Center Coordinator of this site? Confirm its status | Kawagoe | Japan | Not yet recruiting |
| Gunma University Hospital Coordinator of this site? Confirm its status | Maebashi | Japan | Recruiting |
| Gunma Prefectural Cardiovascular Center Coordinator of this site? Confirm its status | Maebashi | Japan | Not yet recruiting |
| Nagoya University Hospital Coordinator of this site? Confirm its status | Nagoya | Japan | Recruiting |
| Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital Coordinator of this site? Confirm its status | Nagoya | Japan | Not yet recruiting |
| National Center for Geriatrics and Gerontology Coordinator of this site? Confirm its status | Ōbu | Japan | Not yet recruiting |
| Osaka General Medical Center Coordinator of this site? Confirm its status | Osaka | Japan | Recruiting |
| Kitasato University Hospital Coordinator of this site? Confirm its status | Sagamihara | Japan | Not yet recruiting |
| Kindai University Hospital Coordinator of this site? Confirm its status | Sakai | Japan | Recruiting |
| Hokkaido Cardiovascular Hospital Coordinator of this site? Confirm its status | Sapporo | Japan | Recruiting |
| The University of Osaka Hospital Coordinator of this site? Confirm its status | Suita | Japan | Recruiting |
| National Cerebral and Cardiovascular Center Coordinator of this site? Confirm its status | Suita | Japan | Not yet recruiting |
| NHO Takasaki General Medical Center Coordinator of this site? Confirm its status | Takasaki | Japan | Recruiting |
| Juntendo University Hospital Coordinator of this site? Confirm its status | Tokyo | Japan | Recruiting |
| Ehime University Hospital Coordinator of this site? Confirm its status | Tōon | Japan | Recruiting |
| Toyota Kosei Hospital Coordinator of this site? Confirm its status | Toyota | Japan | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.