NCT07399236Recruiting
AI-Based Prediction of Liver Metastasis in Colorectal Cancer (A Retrospective Study)
A Multicenter, Retrospective, Observational Study to Develop and Validate a Multimodal Deep Learning Model for Predicting Metachronous Liver Metastasis in Colorectal Cancer Patients After Curative Resection
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
This multicenter, retrospective study aims to develop and validate a multimodal deep learning model for predicting the risk of metachronous liver metastasis in patients with stage I-III colorectal cancer following curative resection. The model will integrate preoperative contrast-enhanced CT imaging, digitized histopathological whole-slide images, and standard clinical-pathological data. The primary objective is to assess the model's discriminatory performance, measured by the area under the receiver operating characteristic curve (AUC), and to compare its predictive accuracy against traditional prognostic factors such as TNM staging and serum carcinoembryonic antigen levels. This research utilizes existing archival data; no direct patient contact or intervention is involved. The ultimate goal is to provide a robust, data-driven tool for improved risk stratification, which could potentially guide personalized surveillance strategies and adjuvant therapy decisions in the future.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1500 (estimated)
- First submitted
- 30 Jan 2026
- Start date
- 1 Jan 2015
- Primary completion date
- 30 Jan 2026
- Lead sponsor
- Tongji Hospital
- Diseases
- Colorectal cancer
- NCT number
- NCT07399236
What you commit to
- Study type: Observational
- Planned participants: 1500
- From 1 Jan 2015 to the primary completion date, 30 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous history of liver surgery or liver transplantation.
- Death within the perioperative period (within 30 days after surgery).
Other illness
- History of other malignant tumors.
Other
- Missing clinical, imaging, or pathological data required for the study.
- Lack of regular follow-up information.
Who the study is looking for
- Age 18-75 years, any gender.
- Histologically confirmed primary colon or rectal adenocarcinoma.
- Underwent curative radical resection (R0 resection) for colorectal cancer.
- Preoperative contrast-enhanced abdominal/pelvic CT scan performed within 1 month before surgery, with acceptable image quality.
- No evidence of distant metastasis (including synchronous liver metastasis) on preoperative or intraoperative exploration.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tongji Hospital Coordinator of this site? Confirm its status | Wuhan | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.