NCT07399288Completed
Postherpetic Neuralgia After Herpes Zoster and Incident Dementia Risk
Postherpetic Neuralgia After Herpes Zoster and Risk of Incident Dementia: Real-World Evidence From an International Matched Cohort With Landmark Analysis
Source: ClinicalTrials.gov · Last updated 2 Nov 2026
Brief summary (registry, in English)
This retrospective observational cohort study uses de-identified electronic health record data from the TriNetX Global Collaborative Network to evaluate whether postherpetic neuralgia after herpes zoster is associated with an increased risk of incident dementia. Adults aged 40 to 120 years with incident herpes zoster between 1 October 2015 and 31 December 2024 are identified using diagnostic codes. Postherpetic neuralgia is defined by International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes B02.22 or B02.29 recorded between 90 and 365 days after the index herpes zoster date, and comparators have no such codes between 90 and 365 days after index. The primary analysis uses 1:1 propensity score matching and a 365-day landmark design, including only individuals alive and free of dementia at the landmark. Time-to-event analyses estimate hazard ratios for incident dementia and related outcomes.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 73404 (actual)
- First submitted
- 3 Feb 2026
- Start date
- 1 Oct 2015
- Primary completion date
- 29 Oct 2026
- Lead sponsor
- China Medical University Hospital
- Diseases
- Alzheimer disease
- NCT number
- NCT07399288
What you commit to
- Study type: Observational
- Participants enrolled: 73404
- From 1 Oct 2015 to the primary completion date, 29 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Any record of the specified outcome before the 365-day landmark.
- Missing data elements required to define exposure status within the prespecified time window.
Who the study is looking for
- Adults aged 40 to 120 years with an incident herpes zoster diagnosis recorded between 1 October 2015 and 31 December 2024 in the TriNetX network.
- A 3-year washout period with no recorded herpes zoster diagnosis before the index date.
- Eligible for analysis at the 365-day landmark after the index date, defined as being alive and free of the specified outcome at the landmark.
Age in the registry: 40 years to 120 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| China Medical University Hospital Coordinator of this site? Confirm its status | Taichung | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.