The Safety and Efficacy of Direct SLT in Pseudoexfoliation Glaucoma

Prior treatment

• Prior incisional glaucoma surgery or glaucoma-related procedures in the study eye
• Any prior refractive surgery

Other illness

• A history of any significant cataract required during study duration or cataract surgery in the last 6 months
• History of ocular inflammation and infection
• Patients who are pregnant or have any clinically relevant systemic disease that may prevent them from reliably completing follow-up visits

Lab values

• Prior laser trabeculoplasty (ALT/SLT)

Other

• Any contraindication to SLT or unable to have DSLT
• Angle closure glaucoma or any other types of glaucoma other than PXFG
• H/o LPI within last 6 months
• Vulnerable populations that cannot provide proper informed consent will not be enrolled, such as children, prisoners, handicapped, or mentally disabled persons, or economically or educationally disadvantaged persons

• Adult patients diagnosed with pseudoexfoliation glaucoma (PXFG), with optic neuropathy consistent with glaucomatous damage of any severity
• Open iridocorneal angle by gonioscopy, defined as a Shafer Grade II or greater
• Treatment naive, or washed out IOP ranging from ≥18-35 mmHg
• Able to complete medication washout safely and all follow-up visits
• Participants must have a best correct visual acuity of 20/40 or better in the study eye(s), be able to undertake a reliable Humphrey visual field (HVF) (defined as fixation losses, false positives and false negatives less than 33%), and must have field loss no worse than -20 dB in treatment eye