NCT07401771Recruiting
Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction
Source: ClinicalTrials.gov · Last updated 20 Aug 2026
Brief summary (registry, in English)
The purpose of this study is to internally validate low-field Ex-CMR as a noninvasive tool for diagnosing, phenotyping, and risk stratifying HFpEF in patients with exertional dyspnea.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 3 Feb 2026
- Start date
- 1 Nov 2026
- Primary completion date
- 31 Mar 2028
- Lead sponsor
- Mayo Clinic
- Diseases
- Heart failure
- NCT number
- NCT07401771
What you commit to
- Study type: Observational
- Planned participants: 400
- From 1 Nov 2026 to the primary completion date, 31 Mar 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Cardiac implants, mechanical or biological valve, causing artifacts that compromise the quality of data
- Hospitalization for heart failure in the preceding 30 days.
- Myocardial infarction or unstable angina pectoris
- Other causes of dyspnea as indicated in patients' medical history based upon the opinion of the PI, such as restrictive cardiomyopathy or infiltrative conditions (e.g., amyloidosis), hypertrophic obstructive cardiomyopathy, primary pulmonary arterial hypertension, more than moderate chronic obstructive pulmonary disease, right heart failure due to pulmonary disease, complex congenital heart disease, severe anemia, or more than moderate mitral or aortic heart valve disease).
Other
- Contraindication for low-field CMR, as indicated in MRI safety screening checklist (Research Document #1)
- Patient inability or unwillingness to undergo Ex-CMR
- Large R-R interval variation, caused by frequent premature ventricular contractions or non-sinus rhythms such as persistent atrial fibrillation, which, in the opinion of the investigators, compromises the quality of data acquisition, image analysis and disrupts the consistency of the cohorts
- Planned coronary, carotid, or peripheral artery revascularization
Who the study is looking for
- Informed consent obtained
- Three groups will be enrolled:
- HFpEF (cardiologist-adjudicated diagnosis as verified by PI, EF≥50%)
- Non-cardiac dyspnea (patients have dyspnea but were found on invasive exercise testing not to have HFpEF).
- Healthy volunteers with no history of dyspnea or effort intolerance.
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.