NCT07402954Recruiting
Stimulation of External Carotid Artery Circulation
Feasibility and Safety of Endovascular Bipolar Stimulation of the Middle Meningeal Artery for Refractory Headaches (MMA-Stim)
Source: ClinicalTrials.gov · Last updated 20 Feb 2026
Brief summary (registry, in English)
This study is testing a new approach to help people with migraine headaches. Researchers want to find out if using electrical stimulation to affect blood flow in the external carotid artery is safe and practical for helping control headaches. The goal of the study is to determine whether this approach could improve headache symptoms and overall outcomes for people with migraines.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 26 Jan 2026
- Start date
- 16 Jan 2026
- Primary completion date
- Aug 2027
- Lead sponsor
- The University of Texas Medical Branch, Galveston
- Diseases
- Migraine
- NCT number
- NCT07402954
What you commit to
- Study type: Interventional
- Planned participants: 12
- From 16 Jan 2026 to the primary completion date, Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous MMA intervention or craniotomy that could result in MMA occlusion
- Any implanted electronic device (pacemaker, ICD, DBS, VNS, cochlear implant, spinal cord stimulator)
Other illness
- Known allergies to lidocaine
- Seizure disorder, history of seizures, or increased seizure susceptibility
- Hemodynamic instability, any condition where brief hemodynamic shifts may pose risk
- Significant cardiovascular disease (unstable angina, severe arrhythmias, recent MI)
- Active systemic infection
- Vulnerable populations (i.e. pregnant individuals, children, prisoners, individuals lacking decision-making capacity, persons with cognitive impairment, those unable to provide informed consent)
Other
- Intracranial vascular malformations or dural AVF
- Severe autonomic dysfunction
Who the study is looking for
- Age ≥18
- Chronic migraine or status migrainosus, or craniofacial pain refractory to maximal medical therapy who are undergoing MMA IA lidocaine infusion.
- Subject has provided informed consent.
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Texas Medical Branch Coordinator of this site? Confirm its status | Galveston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.