NCT07403890Not yet recruiting
Rewiring the Brain-Immune Axis for Chronic Pain Using Transcranial Magnetic Stimulation in Psoriatic Arthritis
Source: ClinicalTrials.gov · Last updated 11 Feb 2026
Brief summary (registry, in English)
Despite advances in immunomodulatory therapies, many Psoriatic arthritis (PsA) patients experience persistent pain unrelated to clinical active joint inflammation. Recent evidence suggests the Inferior Parietal Lobule (IPL) serves as a neuroimmune hub linking central neural activity with peripheral immune dysregulation. In a prior feasibility study, a single L-IPL-targeted TMS session reduced pain and altered immune signalling in inflammatory arthritis by reducing STAT3 phosphorylation in circulating monocytes. This study builds on those findings by evaluating whether rTMS over 4 weeks can induce sustained immune reprogramming while providing meaningful pain relief.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 16 Jan 2026
- Start date
- 1 Mar 2026
- Primary completion date
- 28 Mar 2028
- Lead sponsor
- NHS Greater Glasgow and Clyde
- Diseases
- Psoriasis, Psoriatic arthritis
- NCT number
- NCT07403890
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Mar 2026 to the primary completion date, 28 Mar 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications to MRI (e.g. metal implants/ pacemaker).
Other illness
- Severe physical impairment (e.g. blindness, deafness, paraplegia) Pregnant, planning pregnancy or breast feeding.
- Contraindications to TMS (e.g. history of seizures).
- Serious infection including sepsis, tuberculosis and opportunistic infections such as invasive fungal infections.
- Major confounding neurological disease including Multiple
- Sclerosis, Stroke, Traumatic Brain Injury, Parkinson's Disease, Alzheimer's Disease
Other
- Inability to provide written informed consent.
- Severe claustrophobia precluding MRI.
Who the study is looking for
- Adults ≥ 18 years ≤ 75 years
- Diagnosis of PsA according to CASPAR (Classification Criteria for Psoriatic Arthritis).
- Low disease activity (no more than one joint with clinically active swelling) or remission
- Chronic pain for at least 3 months and VAS (Visual Analogue Scale) pain ≥30 mm
- Stable treatment ≥3 months prior to entering the study
- Able and willing to maintain medication for the duration study
- Able to undergo MRI and TMS procedures
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Queen Elizabeth University Hospital Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.