NCT07404319Not yet recruiting
Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia
Randomised Control Trial of Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia
Source: ClinicalTrials.gov · Last updated 11 Feb 2026
Brief summary (registry, in English)
Cognitive impairment is a major determinant of disability in schizophrenia. Aerobic exercise improves global cognition in schizophrenia, particularly working memory and attention/vigilance. Transcranial direct current stimulation (tDCS) targeting frontal regions has shown promise for cognitive deficits, including working memory improvements in some studies. This randomized 2×2 factorial trial will test the independent and combined effects of supervised aerobic exercise and prefrontal tDCS on cognition in treatment resistant schizophrenia, measured using the MATRICS Consensus Cognitive Battery (MCCB).
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 160 (estimated)
- First submitted
- 4 Feb 2026
- Start date
- 23 Feb 2026
- Primary completion date
- 30 Jan 2028
- Lead sponsor
- Kit Wa Chan
- Diseases
- Schizophrenia
- NCT number
- NCT07404319
What you commit to
- Study type: Interventional
- Planned participants: 160
- From 23 Feb 2026 to the primary completion date, 30 Jan 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Neurological disorder (e.g., epilepsy, stroke) or significant head injury
Other
- Implanted electronic devices / contraindications to tDCS; scalp lesions at electrode sites
- Medical contraindications to moderate aerobic exercise
- Substance dependence within 3 months (except nicotine)
- Pregnancy
Who the study is looking for
- DSM 5 schizophrenia-spectrum disorders
- Treatment resistant schizophrenia: inadequate response to ≥2 antipsychotics of adequate dose/duration
- Clinically stable ≥4 weeks
- Able to provide informed consent
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Hong Kong Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.