NCT07404852Recruiting
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct 2
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 65 (estimated)
- First submitted
- 4 Feb 2026
- Start date
- Feb 2026
- Primary completion date
- Nov 2027
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Stroke
- NCT number
- NCT07404852
What you commit to
- Study type: Interventional
- Planned participants: 65
- From Feb 2026 to the primary completion date, Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Chronic or acute infection, Recent surgery, active immune disease
- patients' undergoing active cancer or immunosuppressive/modulating therapy
- patients with sustained bradycardia on arrival with a heart rate \<50 beats per minute.
Age
- \<18 years old
Other
- patients with presumed chronic large vessel occlusions
- NIHSS\<6
- pre-morbid modified Rankin score (mRS) \>2
- unable to initiate treatment under 24 hours from symptom discovery
- life expectancy \<3 months
Who the study is looking for
- Adult patients who present with acute ischemic strokes due to large vessel occlusions
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Barnes-Jewish Hospital Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.