NCT07405268Active, not recruiting
Evaluation of the Effects of Levodopa-Benserazide Drug Combination on Periodontal Status in Patients With Parkinson's Disease
The Effect of Levodopa-Benserazide Combination on Periodontal Status in Patients With Parkinson's Disease: A Cross-Sectional Study
Source: ClinicalTrials.gov · Last updated 4 Sept 2026
Brief summary (registry, in English)
The aim of this study is to evaluate the effects of Levodopa-Benserazide drug combination on periodontal status and salivary cytokine levels in patients with Parkinson's disease. The study includes four groups: Parkinson's patients with periodontitis, periodontally healthy Parkinson's patients, participants without Parkinson's with periodontitis, and periodontally healthy participants without Parkinson's. Clinical periodontal parameters (Plaque Index, Gingival Index, Bleeding on Probing, Pocket Depth, and Clinical Attachment Loss) will be recorded. Unstimulated saliva samples will be collected to analyze the levels of TNF-alpha, RANTES, IL-10, IL-13, Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Malondialdehyde (MDA).
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 136 (estimated)
- First submitted
- 2 Feb 2026
- Start date
- Feb 2026
- Primary completion date
- Oct 2026
- Lead sponsor
- Saglik Bilimleri Universitesi
- Diseases
- Parkinson disease
- NCT number
- NCT07405268
What you commit to
- Study type: Observational
- Planned participants: 136
- From Feb 2026 to the primary completion date, Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Radiotherapy/chemotherapy within the last 6 months.
Other illness
- Oral, respiratory, or digestive system diseases within the last 3 months.
- Dementia or inability to provide consent.
- Serious active illnesses or substance abuse.
- Diabetes mellitus.
Other
- Active smoking.
- Comprehensive periodontal treatment within the last month.
- Fewer than 16 natural teeth.
- Use of full or removable partial dentures.
- Antibiotic treatment within the last 3 months.
- Probiotic use within the last month.
- Use of oral antiseptics within the last month.
Who the study is looking for
- Diagnosis of Parkinson's Disease according to United Kingdom Parkinson's Disease Society Brain Bank Criteria (for study group).
- Systemically healthy individuals (for control group).
- Willingness to participate and sign informed consent.
Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sağlık Bilimleri Üniversitesi Gülhane Diş Hekimliği Fakültesi Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.