NCT07407231Recruiting
Combined Chemotherapy And Ablative Radiotherapy (SBRT) As First-Line Treatment In Locally Advanced Inoperable Pancreatic Cancer (SBRT-PANC)
Efficacy Of Combination Chemotherapy And Ablative Radiotherapy (SBRT) In The First-Line Treatment Of Locally Advanced Inoperable Pancreatic Cancer
Source: ClinicalTrials.gov · Last updated 17 Feb 2026
Brief summary (registry, in English)
This prospective interventional clinical study evaluates the efficacy and safety of combining systemic chemotherapy followed by ablative stereotactic body radiotherapy (SBRT) as first-line treatment in adult patients with locally advanced, inoperable pancreatic cancer. The study aims to determine the response rate after SBRT delivered following initial chemotherapy, as well as time to disease progression and treatment-related toxicity. Patients receive standard first-line chemotherapy and, in the absence of disease progression, undergo ablative SBRT to the primary tumor, followed by continuation of systemic therapy according to clinical practice. The study is conducted in Slovenia, with patient enrollment expanded to additional participating clinical centers following an approved amendment.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 18 (estimated)
- First submitted
- 6 Feb 2026
- Start date
- 1 Sept 2021
- Primary completion date
- 30 Sept 2024
- Lead sponsor
- Institute of Oncology Ljubljana
- Diseases
- Pancreatic cancer
- NCT number
- NCT07407231
What you commit to
- Study type: Interventional
- Planned participants: 18
- From 1 Sept 2021 to the primary completion date, 30 Sept 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior systemic therapy for locally advanced pancreatic cancer (one or more previous lines of systemic treatment)
- Disease progression after initial chemotherapy prior to SBRT
Other illness
- Metastatic pancreatic cancer
- Any condition that, in the investigator's opinion, would interfere with study participation or evaluation
Who the study is looking for
- Adults aged 18 years and older
- Locally advanced, inoperable pancreatic cancer
- Treated with first-line systemic chemotherapy followed by stereotactic body radiotherapy (SBRT) at participating centers
- Ability to provide written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institute of Oncology Ljubljana Coordinator of this site? Confirm its status | Ljubljana | Slovenia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.