NCT07408154Recruiting
Direct vs Standard SLT for Glaucoma: A Noninferiority Trial
A Randomized Controlled Trial Comparing Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT) in Reducing Intraocular Pressure in Open-Angle Glaucoma
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 172 (estimated)
- First submitted
- 6 Feb 2026
- Start date
- 27 Apr 2026
- Primary completion date
- 31 Oct 2027
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Glaucoma, High blood pressure
- NCT number
- NCT07408154
What you commit to
- Study type: Interventional
- Planned participants: 172
- From 27 Apr 2026 to the primary completion date, 31 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- IOP \>35 mmHg despite therapy
- Recent ocular surgery (\<6 months)
- Contraindications to study medications or procedures
Other illness
- Cognitive impairment preventing consent
Other
- Angle-closure or secondary glaucomas
- Corneal pathology interfering with laser or IOP measurement
Who the study is looking for
- Age ≥18 years
- Diagnosis of OAG (including exfoliative or pigmentary) or OHT
- Gonioscopically open angle (visible scleral spur 360°)
- Ability to consent and comply with follow-up
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| MUSC Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.