NCT07409324Not yet recruiting
Prophylactic Use of APRV Before Extubation in Morbidly Obese Patients After Cardiac Surgery.
Prophylactic Use of Airway Pressure Release Ventilation (APRV) Prior to Extubation in Morbidly Obese Patients Undergoing Elective Cardiac Surgery: Impact on Pulmonary Function, Oxygenation, and ICU Outcomes.
Source: ClinicalTrials.gov · Last updated 13 Feb 2026
Brief summary (registry, in English)
Morbidly obese patients undergoing open heart surgery are at increased risk of breathing problems after removal of the breathing tube due to reduced lung function and chest wall restriction following surgery. These complications may result in poor oxygenation, respiratory failure, and prolonged ICU stay. Airway Pressure Release Ventilation (APRV) is a mechanical ventilation mode that improves lung recruitment and oxygenation. This study aims to evaluate whether the prophylactic use of APRV after ICU admission, compared with conventional lung-protective mechanical ventilation, improves oxygenation, lung function, and ICU outcomes in morbidly obese patients undergoing elective cardiac surgery. Patients will be randomly assigned to receive either APRV or conventional ventilation during postoperative mechanical ventilation, followed by standard weaning and extubation. Outcomes include oxygenation index, lung ultrasound findings, need for reintubation, and ICU clinical outcomes.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 180 (estimated)
- First submitted
- 24 Jan 2026
- Start date
- 1 Feb 2026
- Primary completion date
- Oct 2026
- Lead sponsor
- Ain Shams University
- Diseases
- Obesity
- NCT number
- NCT07409324
What you commit to
- Study type: Interventional
- Planned participants: 180
- From 1 Feb 2026 to the primary completion date, Oct 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with history of previous spontaneous pneumothorax or postoperative pneumothorax.
Other illness
- Severe pulmonary disease (e.g., COPD GOLD III/IV, home oxygen therapy, and pulmonary fibrosis).
- Intracranial hypertension or contraindication to APRV. Hemodynamically unstable on admission (MAP less than 65 mmHg) Vasopressor/inotropic score (VIS) more than 10 Requirement for postoperative extracorporeal membrane oxygenation (ECMO) or intra-aortic balloon pump (IABP).
Other
- Inability to obtain informed consent
Who the study is looking for
- Adult patients aged 18-65 year of both sex.
- Morbidly obese patients (body mass index ≥ 40 kg/m² or ≥ 35 kg/m² with obesity-related comorbidities)
- Scheduled for elective cardiac surgery (CABG, valve, or combined) requiring cardiopulmonary bypass
- Planned postoperative admission to the cardiac surgical intensive care unit
- Patients eligible for mechanical ventilation with planned early extubation within 6-12 hours postoperatively
- Ability to provide written informed consent
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.