NCT07411560RecruitingPhase 1
A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or Obese
Single-centre Study Investigating the Role of Long-acting Subcutaneous Glucose-dependent Insulinotropic Polypeptide Receptor Agonist (GIP RA) in Combination With Long-acting Subcutaneous Amylin Receptor Agonist on Gastrointestinal Tolerability in Participants With Overweight or Obesity
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
This trial is being done to look at the safety and effect of combining cagrilintide and NNC0480-0389 in people living with overweight and obesity compared to taking cagrilintide alone. In one period participants will get two medicines: cagrilintide and NNC0480-0389. In the other period, participants will get cagrilintide together with a placebo version of NNC0480-0389.The placebo looks like the real treatment but does not have any active medicine in it. Cagrilintide and NNC0480-0389 is a new medicine being tested to help people with type 2 diabetes and/or overweight or obesity. The trial medicines is not yet approved for use outside of clinical trials. Participants will receive the trial medicines the way the trial doctor has described. The study will last for about 4.5 months.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 9 Feb 2026
- Start date
- 9 Feb 2026
- Primary completion date
- 26 Jan 2027
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- NCT number
- NCT07411560
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 100
- From 9 Feb 2026 to the primary completion date, 26 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current participation (i.e., dosing) in any other interventional clinical study within 90 days before screening.
- Treatment with any medication prescribed for the indication of obesity or weight management within 90 days before screening, including incretin-based treatment(s).
- Previous or planned (during the study period) obesity treatment with surgery. However, the following are allowed:
- Liposuction and/or abdominoplasty, if performed greater than symbol (\>) 1 year before screening.
- Adjustable gastric banding, if the band has been removed \> 1 year before screening.
- Intragastric balloon, if the balloon has been removed \> 1 year before screening.
- Duodenal-jejunal bypass liner (e.g., Endobarrier), if the sleeve has been removed \> 1 year before screening.
Other illness
- Known or suspected hypersensitivity to study intervention(s) or related products.
- Any condition which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol.
Other
- Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using highly effective contraceptive method.
Who the study is looking for
- Female at birth.
- Age 18-64 years (both inclusive) at the time of signing the informed consent.
- Body mass index (BMI) between 27.0 kilograms per square meter (kg/m\^2) and 39.9 kg/m\^2 (both inclusive) at screening.
- Overweight should be due to excess adipose tissue, as judged by the investigator.
- Considered eligible with suitable veins for cannulation or repeated venepuncture, as judged by the investigator.
- No clinically significant findings during medical history, physical examination, vital signs, electrocardiogram or clinical laboratory tests at the screening visit, as assessed by the investigator.
Age in the registry: 18 years to 64 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Parexel Research Unit Coordinator of this site? Confirm its status | Harrow | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.