NCT07412028Recruiting
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS)
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+/- 5 years) and Body mass index (+/- 5kg/m2).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 81 (estimated)
- First submitted
- 27 Jan 2026
- Start date
- 21 Jul 2026
- Primary completion date
- Jan 2028
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- NCT number
- NCT07412028
What you commit to
- Study type: Interventional
- Planned participants: 81
- From 21 Jul 2026 to the primary completion date, Jan 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking corticosteroids or antiretrovirals ;
- Taking estrogen-progestin therapy;
Other illness
- Hepato-cellular insufficiency (TP \< 50%) ;
- Diabetic patients on insulin : type 1 diabetes or pancreatectomised patients
- Other known causes of hyperandrogenism (21-hydroxylase block, Cushing's syndrome, ovarian tumor).
Lab values
- \- Severe renal insufficiency (GFR \< 30 ml/min) ;
Other
- Menopausal women ;
- Pregnant woman
- Breastfeeding woman
Who the study is looking for
- Women aged ≥ 18 years and \< 45 years ;
- Discontinuation of estrogen-progestin therapyfor at least 3 months ;
- Signed informed consent ;
- Social security affiliation.
- Case (n=25):
- \- Patient with a lipodystrophic syndrome due to a known pathogenic variant of the LMNA gene.
- Control (n=50), :
- \- patient consulting for polycystic ovary syndrome (PCOS according to the Rotterdam criteria) in day hospital matched on age +/-5 years and BMI+/-5 kg/m2.
Age in the registry: 18 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service Endocrinologie, Hôpital St Antoine Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.