NCT07412704RecruitingPhase 1/2
A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis
A Phase 1/2a, Open-label, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of BMS-986528 in Participants With Refractory Rheumatoid Arthritis
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary evidence of disease-modifying effect of BMS-986528 in participants with refractory, difficult-to-treat rheumatoid arthritis (RA).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 84 (estimated)
- First submitted
- 9 Feb 2026
- Start date
- 6 Oct 2026
- Primary completion date
- 30 Oct 2029
- Lead sponsor
- Bristol-Myers Squibb
- Diseases
- Rheumatoid arthritis
- NCT number
- NCT07412704
- EU CT number
- 2025-520666-22-00
- EudraCT number
- 2025-520666-22
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 84
- From 6 Oct 2026 to the primary completion date, 30 Oct 2029
- 39 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- Juvenile arthritis or onset of inflammatory arthritis before age 18.
Other
- Seronegative RA participants in whom polymyalgia rheumatica has not been ruled out.
- Active fibromyalgia with pain symptoms or signs that would interfere with joint assessment.
- Other protocol-defined Inclusion/Exclusion criteria apply.
Who the study is looking for
- \- Adult participants with rheumatoid arthritis (RA) who meet definition of difficult-to-treat.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (39)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - 0049 Coordinator of this site? Confirm its status | Leuven | Belgium | Not yet recruiting |
| Local Institution - 0048 Coordinator of this site? Confirm its status | Merksem | Belgium | Not yet recruiting |
| Local Institution - 0083 Coordinator of this site? Confirm its status | Aparecida de Goiânia | Brazil | Not yet recruiting |
| Local Institution - 0033 Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Not yet recruiting |
| Local Institution - 0082 Coordinator of this site? Confirm its status | Valinhos | Brazil | Not yet recruiting |
| Universitaetsspital Bern, Inselspital Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
| Hôpitaux Universitaire de Genève Coordinator of this site? Confirm its status | Geneva | Switzerland | Recruiting |
| Local Institution - 0006 Coordinator of this site? Confirm its status | Beijing | China | Not yet recruiting |
| Local Institution - 0080 Coordinator of this site? Confirm its status | Guangzhou | China | Not yet recruiting |
| Local Institution - 0007 Coordinator of this site? Confirm its status | Nanchang | China | Not yet recruiting |
| Local Institution - 0020 Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
| Local Institution - 0001 Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
| Local Institution - 0010 Coordinator of this site? Confirm its status | Zhengzhou | China | Not yet recruiting |
| Charite Research Organisation GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Universitaetsklinikum Koeln AöR Coordinator of this site? Confirm its status | Cologne | Germany | Recruiting |
| St. Elisabeth Gruppe GmbH Katholische Kliniken Rhein-Ruhr Coordinator of this site? Confirm its status | Herne | Germany | Recruiting |
| LMU Klinikum Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Recruiting |
| St. Josef Stift GmbH Coordinator of this site? Confirm its status | Sendenhorst | Germany | Recruiting |
| Complexo Hospitalario Universitario A Coruña Coordinator of this site? Confirm its status | A Coruña | Spain | Recruiting |
| Hospital Universitario Reina Sofia Coordinator of this site? Confirm its status | Córdoba | Spain | Recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| Humanitas Mirasole S.p.A. Coordinator of this site? Confirm its status | Rozzano | Italy | Recruiting |
| Local Institution - 0053 Coordinator of this site? Confirm its status | México | Mexico | Not yet recruiting |
| Biokinetica S.A. Coordinator of this site? Confirm its status | Jozefow | Poland | Not yet recruiting |
| Local Institution - 0060 Coordinator of this site? Confirm its status | Ivano-Frankivsk | Ukraine | Not yet recruiting |
| Local Institution - 0064 Coordinator of this site? Confirm its status | Kyiv | Ukraine | Not yet recruiting |
| Local Institution - 0063 Coordinator of this site? Confirm its status | Poltava | Ukraine | Not yet recruiting |
| Local Institution - 0061 Coordinator of this site? Confirm its status | Ternopil | Ukraine | Not yet recruiting |
| Local Institution - 0050 Coordinator of this site? Confirm its status | Aurora | United States | Not yet recruiting |
| Colorado Blood Cancer Institute Coordinator of this site? Confirm its status | Denver | United States | Recruiting |
| Local Institution - 0051 Coordinator of this site? Confirm its status | DeSoto | United States | Withdrawn |
| Local Institution - 0068 Coordinator of this site? Confirm its status | La Jolla | United States | Not yet recruiting |
| Local Institution - 0070 Coordinator of this site? Confirm its status | Loma Linda | United States | Not yet recruiting |
| Local Institution - 0079 Coordinator of this site? Confirm its status | New York | United States | Not yet recruiting |
| Local Institution - 0081 Coordinator of this site? Confirm its status | New York | United States | Not yet recruiting |
| Local Institution - 0069 Coordinator of this site? Confirm its status | Palo Alto | United States | Not yet recruiting |
| Local Institution - 0071 Coordinator of this site? Confirm its status | Philadelphia | United States | Not yet recruiting |
| Local Institution - 0066 Coordinator of this site? Confirm its status | Portland | United States | Not yet recruiting |
| Local Institution - 0055 Coordinator of this site? Confirm its status | South Miami | United States | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.