NCT07413718Recruiting
Inspiratory Muscle Training in Amiotrophyc Lateral Sclerosis
Efficacy of Inspiratory Muscle Training in Patients With Amyotrophic Lateral Sclerosis: A Clinical Trial
Source: ClinicalTrials.gov · Last updated 17 Feb 2026
Brief summary (registry, in English)
Amyotrophic Lateral Sclerosis (ALS) progressively damages the nerve cells responsible for voluntary muscle movement. Over time, this leads to weakness in different muscles such as those used for movement or breathing. Breathing problems are one of the main causes of complications and reduced survival in people with ALS. This happens because the inspiratory muscles-those that help draw air into the lungs-gradually lose strength. The study has the aim to explore the benefits of training inspiratory muscles in ALS patients in order to maintain the setrength of these muscles for as long as possible and look the impact on respiratory function.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 44 (estimated)
- First submitted
- 15 Dec 2025
- Start date
- 1 Sept 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University Ramon Llull
- Diseases
- ALS (motor neurone disease)
- NCT number
- NCT07413718
What you commit to
- Study type: Interventional
- Planned participants: 44
- From 1 Sept 2025 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any contraindication to the use of IMT. Severe psychiatric illness.
Other
- Patients with signs of respiratory muscle weakness (MIP and MEP below the LLN and abnormal decubitus tests19-21)
- Nocturnal hypoventilation
- Inability to perform the measurement tests
- Inability to understand and perform the exercises
Who the study is looking for
- Patients diagnosed with spinal ALS
- men and women
- diagnosis date less than two years ago, according to the "El Escorial" criteria (Appendix 2)
- PIM above the lower limit of normal
- Preserved lung function (FVC ≥ 80%, FEV1 ≥ 80%, FEV1/FVC ≥ 80%) and normal values in supine position
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ADELA Gipuzkoa Coordinator of this site? Confirm its status | Donostia / San Sebastian | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.