NCT07414732Recruiting
Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors
The "Savvy for Stroke Survivors" Study: Testing a Novel Tool to Help Stroke Survivors Take Their Medication
Source: ClinicalTrials.gov · Last updated 20 May 2026
Brief summary (registry, in English)
The goal of this study is to test if Savvy, a multimodal intervention (consisting of psychological exercises, a weekly pill organizer, and a text message reminder system) can improve medication adherence in stroke survivors. The main questions it aims to answer are: * Can the Savvy tool improve medication adherence in stroke survivors compared to usual care? * Does the use of the Savvy tool lead to better blood pressure control after a stroke? The investigators will compare the use of the Savvy intervention to a control group that receives usual care, including a package of educational materials. The study consists of the following components: * Participants will receive the Savvy intervention or usual care. The intervention package consists of short psychological exercises over the phone, a weekly medication organizer to support daily medication intake, and text message reminders to take medication and refill the medication box. Participants in the control group will receive usual care, including educational materials about the importance of blood pressure and medication. * All participants will receive a free home blood pressure monitor and will be requested to measure their blood pressure at certain time points during the study. * Participants will be enrolled in the study for 6 months and will have virtual follow-up calls at 3 and 6 months.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 9 Feb 2026
- Start date
- 31 Mar 2026
- Primary completion date
- 30 Apr 2027
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Stroke
- NCT number
- NCT07414732
What you commit to
- Study type: Interventional
- Planned participants: 150
- From 31 Mar 2026 to the primary completion date, 30 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prescribed a more than three scheduled daily medication doses.
- Prescribed a complex medication regimen requiring more than five additional oral medications per dose time.
- Has upper extremity impairments or other physical limitations that prevent safe use of the medication box or BP monitor.
- Participation in another intervention trial targeting medication adherence or BP control.
Other illness
- Diagnosed with secondary hypertension or other BP conditions not managed with standard oral antihypertensives.
- Lives in an environment where the medication organizer cannot be safely or consistently accessed, such as in temporary housing, shelters, or unstable living conditions.
- Diagnosed with moderate-to-severe cognitive impairment, dementia, or active psychiatric instability that precludes informed consent or reliable participation.
- Known allergy or contraindication to the materials used in the BP monitor or the medication box.
Other
- Planned relocation or anticipated unavailability for the 12-month study period.
Who the study is looking for
- Participants must be between the ages of 18 years old and 99 years old at the time of consent.
- Self-reported primary diagnosis of stroke (ischemic or hemorrhagic) within the past 12 months, without structural, traumatic or secondary causes (including aneurysm, arteriovenous malformation, or tumor).
- Currently prescribed an antihypertensive regimen.
- Currently less than optimal adherence to medication, defined as a score \<25 on the Medication Adherence Report Scale (MARS-5).
- Cognitively able to manage medications independently, defined as a score of \>4 on the Six-Item Screener (SIS) for cognitive impairment.
- Speaks English sufficiently to complete consent and study procedures.
- Has access to a phone that can receive text messages and is able to participate in scheduled phone-based follow-up assessments.
- Uses, or willing to start using, a single pharmacy chain for prescription refills and is willing to provide consent for the study team to contact the pharmacy to retrieve prescription refill data.
- Willing and able to provide informed consent.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.