NCT07415213Active, not recruiting
Mapping Metabolic Organ Plasticity in Energy Adaptation
Source: ClinicalTrials.gov · Last updated 17 Feb 2026
Brief summary (registry, in English)
Brief Summary (Plain Language) Many people who lose weight experience a slowdown in their metabolism that is greater than expected. This response, called metabolic adaptation, makes it harder to continue losing weight or to keep weight off over time. The biological reasons for this slowdown are not fully understood. Some organs in the body, especially the liver and kidneys, use a large amount of energy even when the body is at rest. Although these organs make up only a small portion of body weight, they account for a large share of daily energy use. Changes in the size or function of these organs may play an important role in metabolic adaptation, but this has not been well studied in humans. The purpose of this study is to understand how different lifestyle approaches affect metabolic adaptation and the size of key metabolic organs. Specifically, the study compares three common strategies: * resistance training without calorie restriction, * a calorie-restricted diet, and * time-restricted eating (eating all daily food within a limited time window). Adults with overweight will take part in one of these approaches for 10 weeks. Before and after the study period, participants will undergo advanced measurements, including magnetic resonance imaging (MRI) scans to measure liver and kidney size, tests to measure resting metabolism, and assessments of body composition. Some participants will also undergo additional testing to measure daily energy use. By understanding how different lifestyle strategies influence metabolism and organ size, this study aims to improve knowledge about why weight loss is difficult to maintain and to support the development of more personalized approaches to long-term weight management.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- First submitted
- 9 Feb 2026
- Start date
- Feb 2026
- Primary completion date
- Dec 2029
- Lead sponsor
- Tel Aviv University
- Diseases
- Obesity
- NCT number
- NCT07415213
What you commit to
- Study type: Interventional
- Planned participants: 75
- From Feb 2026 to the primary completion date, Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of drugs that affect body metabolism
Other illness
- Severe cardiopulmonary disease (e.g., recent myocardial infarction or unstable angina)
- Other health issues, including cancer, diabetes, thyroid disease, hypertension, or chronic renal failure
- Secondary liver disease (viral, autoimmune, alcoholic, or hepatotoxic)
Other
- Participation in another exercise or weight loss program in the last 6 months
- Non-stable weight (\>±5%) over the past 6 months
- Smoking within the past 6 months
- Post-menopause
- Breastfeeding
- Pregnancy or having been pregnant within the past 6 months
- Contraindication for MRI scans (e.g., tattoos, intrauterine devices, permanent makeup, etc.)
- Musculoskeletal or neuromuscular impairments that preclude exercise training
- Cognitive impairments
- Alcohol consumption above 20 g/day for women or 30 g/day for men
Who the study is looking for
- Sedentary men and women aged 25-60 years
- Body mass index (BMI) of 25-35 kg/m²
Age in the registry: 25 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sylvan Adams Sport Institute Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.