A Coronary Computed Tomography Angiography-guided Intervention for High Risk Cardiovascular Disease Population in Rural China

Prior treatment

• Unwillingness or inability to undergo coronary CTA examination (e.g., previous history of severe contrast allergy, claustrophobia, or inability to cooperate with scanning and breath-holding for physical reasons in study participants)

Other illness

• Typical angina symptoms, known coronary artery disease, or other major atherosclerotic cardiovascular disease
• Known cerebrovascular disease (e.g., cerebral hemorrhage, cerebral infarction, etc. )
• Known familial hypercholesterolemia or other inherited disorders of lipid metabolism requiring lipid-lowering therapy
• Presence of active bleeding or diseases with a very high risk of bleeding (e.g., active peptic ulcer disease, gastrointestinal pathologies with increased risk of bleeding, hematologic disorders with increased risk of bleeding, etc.)
• Have a malignant tumor

Lab values

• eGFR \<30 mL/min/1.73m\^2
• Platelet count \<100×10\^9/L

Age

• End-stage diseases such as cirrhosis decompensation, with life expectancy \<3 years
• Lipid-lowering treatment for \>2 years

Other

• Prior invasive or non-invasive coronary angiography within the last 5 years
• Intolerance of all statins
• Pregnant or breastfeeding, planning to become pregnant within the next 3 years
• Poor compliance, unable to cooperate with study investigators
• Investigators consider unsuitable for participants selected for this study

• Administrative villages
• The village has no plans to merge with other villages within 3 years
• The village is at least 2 kilometers away from other participating villages
• The village has a sufficient number of study participants
• The village is able to cooperate with the implementation of the study
• Men or women aged between 40 and 75 years
• Live stably in the province where the study is conducted and no intention to migrate within next 3 years
• Not participating in other clinical trials
• Meet any of the following:
  • (1)Low-Density Lipoprotein Cholesterol (LDL-C) ≥ 4.9 mmol/L or Total Cholesterol (TC) ≥ 7.2 mmol/L (2)Diabetes mellitus (3)Chronic Kidney Disease (CKD) Stage 3-4: estimated Glomerular Filtration Rate (eGFR) 15-59 mL/min/1.73m\^2 (4)With a history of hypertension and 3 risk factors, combined with LDL-C ≥ 1.8 mmol/L or TC ≥ 3.1 mmol/L \[Risk factors (assessed pre-intervention): smoking, low HDL-C, male ≥ 45 years old or female ≥ 55 years old\] (5)With a history of hypertension and 2 risk factors, combined with LDL-C ≥ 2.6 mmol/L or TC ≥ 4.1 mmol/L \[Risk factors (assessed pre-intervention): smoking, low HDL-C, male ≥ 45 years old or female ≥ 55 years old\] 5. Sign the informed consent