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NCT07416409Completed

Effectiveness, Safety, and Tolerability of Anti-HER2 Drugs as Targeted Therapy for Egyptian Patients With ERBB2-Positive Breast Cancer

Source: ClinicalTrials.gov · Last updated 18 Feb 2026

Brief summary (registry, in English)

Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is an aggressive subtype characterized by overexpression of the HER2 receptor. Anti-HER2 therapies such as trastuzumab and pertuzumab are widely used in clinical practice and have improved patient outcomes; however, their effectiveness and safety profiles may vary across populations. This prospective observational cohort study evaluates the real-world effectiveness, safety, and tolerability of single-agent versus combination anti-HER2 therapy among Egyptian patients with erb-b2 receptor tyrosine kinase 2 (ERBB2)-positive breast cancer. The study aims to describe treatment outcomes and identify factors associated with survival and tolerability in routine clinical practice.

Status (registry)
Completed
Study type
Observational
Enrollment
80 (actual)
First submitted
9 Feb 2026
Start date
10 Jun 2023
Primary completion date
20 Jun 2024
Lead sponsor
Deraya University
NCT number
NCT07416409

What you commit to

  • Study type: Observational
  • Participants enrolled: 80
  • From 10 Jun 2023 to the primary completion date, 20 Jun 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior treatment for breast cancer
  • Severe comorbidities preventing safe Anti-HER2 therapy

Other illness

  • Metastatic disease at initial diagnosis

Lab values

  • Left ventricular ejection fraction below normal limit

Age

  • Age \<18 or \>65 years

Other

  • Pregnancy or lactation

Who the study is looking for

  • Pathologically confirmed ERBB2-positive breast cancer
  • Female, aged 18-65 years
  • Performance status 0-2 (WHO criteria)
  • Adequate cardiac, hepatic, and renal function
  • No prior chemotherapy or radiotherapy for breast cancer

Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Dar Al-Salam Cancer Hospital
Coordinator of this site? Confirm its status
CairoEgyptUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.