NCT07416409Completed
Effectiveness, Safety, and Tolerability of Anti-HER2 Drugs as Targeted Therapy for Egyptian Patients With ERBB2-Positive Breast Cancer
Source: ClinicalTrials.gov · Last updated 18 Feb 2026
Brief summary (registry, in English)
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is an aggressive subtype characterized by overexpression of the HER2 receptor. Anti-HER2 therapies such as trastuzumab and pertuzumab are widely used in clinical practice and have improved patient outcomes; however, their effectiveness and safety profiles may vary across populations. This prospective observational cohort study evaluates the real-world effectiveness, safety, and tolerability of single-agent versus combination anti-HER2 therapy among Egyptian patients with erb-b2 receptor tyrosine kinase 2 (ERBB2)-positive breast cancer. The study aims to describe treatment outcomes and identify factors associated with survival and tolerability in routine clinical practice.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 80 (actual)
- First submitted
- 9 Feb 2026
- Start date
- 10 Jun 2023
- Primary completion date
- 20 Jun 2024
- Lead sponsor
- Deraya University
- Diseases
- Metastatic breast cancer
- NCT number
- NCT07416409
What you commit to
- Study type: Observational
- Participants enrolled: 80
- From 10 Jun 2023 to the primary completion date, 20 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment for breast cancer
- Severe comorbidities preventing safe Anti-HER2 therapy
Other illness
- Metastatic disease at initial diagnosis
Lab values
- Left ventricular ejection fraction below normal limit
Age
- Age \<18 or \>65 years
Other
- Pregnancy or lactation
Who the study is looking for
- Pathologically confirmed ERBB2-positive breast cancer
- Female, aged 18-65 years
- Performance status 0-2 (WHO criteria)
- Adequate cardiac, hepatic, and renal function
- No prior chemotherapy or radiotherapy for breast cancer
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dar Al-Salam Cancer Hospital Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.