NCT07417280Recruiting
LIFUS For Neurological Disorders
Clinical Effects of Low-Intensity Focused Ultrasound Neuromodulation in Patients With Neurological and Psychiatric Disorders
Source: ClinicalTrials.gov · Last updated 13 Aug 2026
Brief summary (registry, in English)
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation. Studies in healthy subjects have shown that application of LIFUS to the motor region of the brain can mildly decrease neuron excitability in healthy controls. The purpose of the present study is to evaluate the effects of LIFUS on brain tissue excitability in patients with movement disorders in order to elucidate the therapeutic potential of LIFUS.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 30 Jan 2026
- Start date
- 2 Dec 2025
- Primary completion date
- 31 Dec 2035
- Lead sponsor
- University Health Network, Toronto
- Diseases
- Epilepsy, Parkinson disease
- NCT number
- NCT07417280
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 2 Dec 2025 to the primary completion date, 31 Dec 2035
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving a psychotropic medication or taking recreational substances that in the opinion of the investigator will significantly affect safety of the protocol
Other illness
- History of stroke
- Comorbid dementia
- Has an implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD)
- Major depression/psychiatric disorder that in the opinion of the Investigator will affect patient's understanding of study procedures and willingness to abide by all procedures during the course of the study
- Major systemic illness or infection
Other
- Scored below 22 on the Montreal Cognitive Assessment (MoCA)
- Presence of metal implanted in body that is contraindicated in TMS/MRI
- Pregnancy
Who the study is looking for
- 18-85 years of age
- Patients diagnosed with neurological disorders, (such as epilepsy, brain tumour, movement disorders) or psychiatric disorders (such as substance abuse disorder)
- Patients undergoing medical or surgical treatment (such as DBS) for neurological disorders
Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Toronto Western Hospital, 399 Bathurst St Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.