NCT07417709Not yet recruiting
Interest of Adaptated Physical Activity (APA) on the K Recovery Constant, Reflecting the Rate of Muscle Oxygenation Recovery in Menopausal Women Suffering From Depression
Source: ClinicalTrials.gov · Last updated 18 Feb 2026
Brief summary (registry, in English)
APhyDeM is a randomized controlled study investigating the relationship between adapted physical activity and mitochondrial function in postmenopausal women with major depressive disorder. Depression is associated with metabolic dysfunction, including alterations in mitochondrial activity and inflammatory processes. Physical activity has been shown to influence mitochondrial function, yet individuals with depression frequently experience reduced physical activity levels. This study aims to evaluate whether an adapted physical activity program can improve mitochondrial function compared with a control intervention. Mitochondrial function will be indirectly assessed using near-infrared spectroscopy to measure post-exercise muscle oxygen recovery kinetics. The study compares adapted physical activity with a non-physical therapeutic intervention in postmenopausal women receiving care in a psychiatric day hospital setting.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 52 (estimated)
- First submitted
- 11 Feb 2026
- Start date
- 1 Feb 2026
- Primary completion date
- 31 Oct 2028
- Lead sponsor
- Centre Hospitalier Universitaire de Besancon
- Diseases
- Depression
- NCT number
- NCT07417709
What you commit to
- Study type: Interventional
- Planned participants: 52
- From 1 Feb 2026 to the primary completion date, 31 Oct 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medical contraindication for physical activity (cardio-vascular pathology, and/or previous cardiac disease)
Other illness
- Asthma or other unstabilized condition impairing the ability to perform physical exertion
Other
- Adipose tissue thickness measured on the forearm \> 12 mm causing muscle oxygenation measurement by NIRS to be non contributive
Who the study is looking for
- Menopaused women aged ≥ 40 years old,
- Suffering from a major depressive episode according to international Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-V)
- Presenting a score ≥11 on the 16-item Quick Inventory of Depressive Symptomatology Clinician Rating (QIDS-C16) depression scale
- With a stabilized teatment by antidepressors since at least 4 weeks
Age in the registry: 40 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Besançon Coordinator of this site? Confirm its status | Besançon | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.