NCT07419568Not yet recruiting
Burden of Tuberculosis Among Pregnant and Postpartum Women in Guinea-Bissau
Assessing the Burden of Tuberculosis Among Pregnant and Postpartum Women: Implications for Integrating Tuberculosis Screening Into Routine Antenatal Care in Guinea-Bissau
Source: ClinicalTrials.gov · Last updated 19 Feb 2026
Brief summary (registry, in English)
This study aims to address critical diagnostic and data gaps in tuberculosis (TB) care among pregnant and postpartum women in Guinea-Bissau, a high-burden, resource-limited setting. Recognising that current TB screening during antenatal care (ANC) relies largely on unstructured symptom questions, the study will integrate more systematic and innovative approaches into routine maternal health services. The project will implement the Bandim TBscore II as a structured triage tool to classify symptom severity and guide referrals. To strengthen diagnostic capacity, two novel tools will be evaluated: stool-based GeneXpert testing (a method recommended in children and explored here as a feasible alternative for pregnant women) and artificial intelligence-powered chest X-ray interpretation software designed to enhance TB detection where radiological expertise is lacking. The study will also generate comprehensive, population-based data on TB and TB infection (TBI) among pregnant, postpartum women and women of reproductive age in Guinea-Bissau. The results are intended to inform health policy, both locally and in high-income countries, by providing evidence to improve TB screening protocols and care for this vulnerable group. Ultimately, the study seeks to develop scalable strategies that can be replicated across low- and middle-income countries to advance maternal and child health and support global TB eradication efforts.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 720 (estimated)
- First submitted
- 9 Feb 2026
- Start date
- Feb 2026
- Primary completion date
- Nov 2027
- Lead sponsor
- Aarhus University Hospital
- Diseases
- Tuberculosis
- NCT number
- NCT07419568
What you commit to
- Study type: Interventional
- Planned participants: 720
- From Feb 2026 to the primary completion date, Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receives TB treatment at the time of, or a year prior to, enrolment
Age
- Pregnant women ≤ 15 years of age
Other
- Inability to provide informed consent
- Residing outside of the study area
Who the study is looking for
- Pregnant women ≥ 15 years of age
- Residing in the study
- Attending ANC consultations at health centre in Bandim, Belem or Cuntum
- Must provide informed consent
Age in the registry: 15 years to - · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Projecto Saude de Bandim Coordinator of this site? Confirm its status | Bissau | Guinea-Bissau | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.